| Neoplastic invasion of laryngeal cartilage: reassessment of criteria for diagnosis at MR imaging. | |
MedLine Citation:
|
PMID: 18936314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate whether proposed diagnostic criteria applied to magnetic resonance (MR) images of patients with laryngeal and hypopharyngeal carcinoma may be used to distinguish neoplastic from inflammatory involvement of the laryngeal cartilages. MATERIALS AND METHODS: The radiologic and histopathologic data in 121 consecutive patients with primary squamous cell carcinoma of the larynx (n = 63) or hypopharynx (n = 58) who underwent MR imaging before laryngectomy formed the basis of this retrospective study. Patient consent for retrospective chart review was waived by the institutional review board. All laryngectomy specimens were processed with a dedicated histopathologic whole-organ slice technique. MR images were evaluated by two readers according to established ("old") and proposed ("new") diagnostic criteria on the basis of the signal intensity behavior of cartilage on T2-weighted images and contrast material-enhanced T1-weighted images compared with that of the adjacent tumor. Specifically, with the new criteria, T2-weighted or postcontrast T1-weighted cartilage signal intensity greater than that of the adjacent tumor was considered to indicate inflammation, and signal intensity similar to that of the adjacent tumor was considered to indicate neoplastic invasion. The results of the MR image interpretation were compared with the histologic reference standard. RESULTS: The area under the receiver operating characteristic curve for the new criteria (0.94) was nominally but significantly larger than that for the old criteria (0.92) (P = .01). Overall specificity was significantly improved (82% for new vs 74% for old criteria, P < .001) and was greatest for the thyroid cartilage (75% for new vs 54% for old criteria, P < .001) with the new criteria. The sensitivities of the established and the proposed criteria were identical. CONCLUSION: The proposed MR imaging criteria enable improved differentiation of neoplastic cartilage invasion from peritumoral inflammation. |
Authors:
|
Minerva Becker; Peter Zbären; Jan Walther Casselman; Romain Kohler; Pavel Dulguerov; Christoph D Becker |
Related Documents
:
|
19626474 - Osteochondral defect repair after implantation of biodegradable scaffolds: indirect mag... 19016394 - Mri monitoring of cartilage repair in the knee: a review. 19630944 - Identification of progressors in osteoarthritis by combining biochemical and mri-based ... 9002024 - In vitro magnetic resonance microimaging of experimental osteoarthritis in the rat knee... 1561694 - Cheiro-oral syndrome due to lesions in the corona radiata. 10485074 - Computerized localization of breast lesions from two views. an experimental comparison ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Radiology Volume: 249 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2008 Nov |
Date Detail:
|
Created Date: 2008-10-21 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
|
Languages: eng Pagination: 551-9 Citation Subset: AIM; IM |
Copyright Information:
|
(c) RSNA, 2008. |
Affiliation:
|
Department of Radiology, Geneva University Hospital, Hôpitaux Universitaires de Genève, Geneva 14, Switzerland. minerva.becker@hcuge.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / pathology* Contrast Media Female Humans Hypopharyngeal Neoplasms / pathology*, surgery Laryngeal Cartilages / pathology*, surgery Laryngeal Neoplasms / pathology*, surgery Magnetic Resonance Imaging / methods* Male Middle Aged Neoplasm Invasiveness ROC Curve Retrospective Studies |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media |
| Comments/Corrections | |
Comment In:
|
Radiology. 2008 Nov;249(2):410-2
[PMID:
18936304
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diffusion-weighted imaging in cervical cancer with an endovaginal technique: potential value for imp...
Next Document: Meniscal measurements of T1rho and T2 at MR imaging in healthy subjects and patients with osteoarthr...