Document Detail


Neoplastic invasion in experimental carcinoma of the colon: abnormal differentiation and release of mucus.
MedLine Citation:
PMID:  2350917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carcinomas of the colon were induced in F344 rats with dimethylhydrazine (20 mg/kg for 12 weeks). The invasive edges of the lesions were examined with the electron microscope. As in human colorectal cancer, the invasive edges show neoplastic cells with abnormal differentiation of apical cytoplasmic rootlets and processes at the basal or invasive edge of the cell, 'apical reversal'. Mucous carcinoma cells release material into the interstitial connective tissue matrix. The features may contribute to the complex phenomenon of neoplastic invasion.
Authors:
I Carr; K Orr
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical & experimental metastasis     Volume:  8     ISSN:  0262-0898     ISO Abbreviation:  Clin. Exp. Metastasis     Publication Date:    1990 Jul-Aug
Date Detail:
Created Date:  1990-07-16     Completed Date:  1990-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409970     Medline TA:  Clin Exp Metastasis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / pathology
Animals
Carcinoma / chemically induced,  pathology*,  secretion
Cell Differentiation
Colonic Neoplasms / chemically induced,  pathology*,  secretion
Dimethylhydrazines
Male
Microscopy
Microscopy, Electron
Neoplasm Invasiveness*
Rats
Rats, Inbred F344
Chemical
Reg. No./Substance:
0/Dimethylhydrazines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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