| Neoplastic alterations in subcellular distribution of type 1 alpha protein phosphatase in rat ascites hepatoma cells. | |
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MedLine Citation:
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PMID: 7634244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neoplastic alterations of type 1 alpha protein phosphatase (PP1 alpha) have been studied in rat ascites hepatoma cells, using regenerating liver after partial hepatectomy and normal rat liver as controls. In the particulate fraction of hepatomas, potential PP1 activity and the amount of PP1 alpha were remarkably increased compared with either regenerating or normal livers. In the nuclear fraction, PP1 activity and the amount of PP1 alpha were increased in hepatoma compared with the controls. The nuclear PP1 activity in hepatomas was activated by treatment with CO2+/trypsin, whereas that of normal or regenerating liver was not activated. These characteristic alterations of PP1 alpha in its amount and subcellular distribution may be implicated in malignant phenotype(s) such as uncontrolled cell growth. |
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Authors:
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M Saadat; Y Mizuno; N Takizawa; Y Kakinoki; R Rikuchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 94 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-11 Completed Date: 1995-09-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 165-70 Citation Subset: IM |
Affiliation:
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Section of Biochemistry, Hokkaido University, Sapporo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascites / enzymology* Carcinoma, Hepatocellular / enzymology* Cell Nucleus / enzymology Liver / enzymology* Liver Neoplasms / enzymology* Liver Regeneration* Male Phosphoprotein Phosphatases / metabolism* Rats |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.16/Phosphoprotein Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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