| Neoplastic alteration of a membrane-associated sialidase of rat liver. | |
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MedLine Citation:
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PMID: 2121693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rat liver particulate fraction contains two types of membrane-associated and gangliosides-hydrolyzing sialidase, which have been shown to be identical to two membrane-associated sialidases of rat brain (I and II) chromatographically, immunologically and in substrate specificity. Chromatography on AH-Sepharose 4B of the membrane sialidases of rat primary hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene (MeDAB) further revealed that hepatocarcinogenesis induces a marked decrease in sialidase II but no decrease in sialidase I. Using antisera against sialidases I and II of rat brain, immunoprecipitation studies of the solubilized particulate fractions of rat liver and MeDAB-hepatoma gave results similar to those obtained chromatographically. Using the same immunological technique, sialidase II but not sialidase I was found to be decreased in AH109 A hepatoma and in regenerating and fetal liver. |
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Authors:
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T Miyagi; K Konno; J Sagawa; S Tsuiki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese journal of cancer research : Gann Volume: 81 ISSN: 0910-5050 ISO Abbreviation: Jpn. J. Cancer Res. Publication Date: 1990 Sep |
Date Detail:
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Created Date: 1990-12-13 Completed Date: 1990-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8509412 Medline TA: Jpn J Cancer Res Country: JAPAN |
Other Details:
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Languages: eng Pagination: 915-9 Citation Subset: IM |
Affiliation:
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Biochemistry Laboratory, Tohoku University, Sendai. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / enzymology Cell Membrane / enzymology Liver / enzymology* Liver Neoplasms / enzymology Liver Neoplasms, Experimental / enzymology Male Neuraminidase / metabolism* Precipitin Tests Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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EC 3.2.1.18/Neuraminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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