Document Detail


Neoplastic Plasma Cell Aberrant Antigen Expression Patterns and Their Association with Genetic Abnormalities.
MedLine Citation:
PMID:  24913506     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Little is known about aberrant antigens expression and their association with cytogenetic aberrations in multiple myeloma (MM). We examined the correlation between flow cytometry (FC), and FISH in 167 marrow specimens with MM. Gene expression profiling of CD56, CD117, CD52 and CD20 mRNA in plasma cells (PCs) from total therapy 2 & total therapy 3 patients were also evaluated. Higher expression of CD56 and CD117 is associated with hyperdiploidy. High CD52 mRNA expression was associated with c-MAF and FGFR3 subgroups. Higher expression of CD56 mRNA, but lower KIT expression was noted in association with FGFR3. In contrast, the c-MAF subgroup showed high KIT expression but lacked NCAM mRNA expression. CKS1B amplification showed positive correlation with CD52 (p=0.0065) but negative correlation with CD20 (p=0.0207). These findings indicate that phenotypic differences in MM are associated with distinct genetic subgroups, and potentially important diagnostic and prognostic value.
Authors:
Mohamed E Salama; Shouying Du; Olga Efimova; Nahla M Heikal; Erik Wendlandt; Reha M Toydemir; Sarah South; Sherrie L Perkins; Jerry W Hussong; Fenghuang Zhan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-21     Citation Subset:  -    
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