Document Detail

Neoplastic Plasma Cell Aberrant Antigen Expression Patterns and Their Association with Genetic Abnormalities.
MedLine Citation:
PMID:  24913506     Owner:  NLM     Status:  Publisher    
Abstract Little is known about aberrant antigens expression and their association with cytogenetic aberrations in multiple myeloma (MM). We examined the correlation between flow cytometry (FC), and FISH in 167 marrow specimens with MM. Gene expression profiling of CD56, CD117, CD52 and CD20 mRNA in plasma cells (PCs) from total therapy 2 & total therapy 3 patients were also evaluated. Higher expression of CD56 and CD117 is associated with hyperdiploidy. High CD52 mRNA expression was associated with c-MAF and FGFR3 subgroups. Higher expression of CD56 mRNA, but lower KIT expression was noted in association with FGFR3. In contrast, the c-MAF subgroup showed high KIT expression but lacked NCAM mRNA expression. CKS1B amplification showed positive correlation with CD52 (p=0.0065) but negative correlation with CD20 (p=0.0207). These findings indicate that phenotypic differences in MM are associated with distinct genetic subgroups, and potentially important diagnostic and prognostic value.
Mohamed E Salama; Shouying Du; Olga Efimova; Nahla M Heikal; Erik Wendlandt; Reha M Toydemir; Sarah South; Sherrie L Perkins; Jerry W Hussong; Fenghuang Zhan
Related Documents :
23497256 - Effects of hdm2 antagonism on sunitinib resistance, p53 activation, sdf-1 induction, an...
15934306 - Correlation between loss of pten expression and pkb/akt phosphorylation in hepatocellul...
18948276 - Arabidopsis transient expression analysis reveals that activation of glabra2 may requir...
7671256 - Human c-myb is expressed in cervical carcinomas and transactivates the hpv-16 promoter.
8557696 - Overexpression of thymidine kinase mrna eliminates cell cycle regulation of thymidine k...
12051736 - Enhanced expression of insulin-like growth factor binding protein-3 sensitizes the grow...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-21     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Gene Expression Based Predictor for High Risk Myeloma Treated with Intensive Therapy and Autologou...
Next Document:  Allogeneic Transplant Following Brentuximab Vedotin in Patients with Relapsed or Refractory Hodgkin ...