| Neoplastic meningitis from solid tumors: new diagnostic and therapeutic approaches. | |
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MedLine Citation:
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PMID: 21795431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neoplastic meningitis is a result of the spread of malignant cells to the leptomeninges and subarachnoid space and their dissemination within the cerebrospinal fluid. This event occurs in 4%-15% of all patients with solid tumors and represents an important prognostic factor for poor survival. Neoplastic meningitis should be diagnosed in the early stages of disease to prevent important neurological deficits and to provide the most appropriate treatment. Despite new diagnostic approaches developed in recent years, such as positron emission tomography-computed tomography and new biological markers, the combination of magnetic resonance imaging without and with gadolinium enhancement and cytology still has the greatest diagnostic sensitivity. Recently, no new randomized studies comparing intrathecal (i.t.) with systemic treatment have been performed, yet there have been a few small phase II studies and case reports about new molecularly targeted substances whose successful i.t. or systemic application has been reported. Trastuzumab, gefitinib, and sorafenib are examples of possible future treatments for neoplastic meningitis, in order to better individualize therapy thus allowing better outcomes. In this review, we analyze the most recent and interesting developments on diagnostic and therapeutic approaches. |
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Authors:
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Giuseppe Lombardi; Fable Zustovich; Patrizia Farina; Alessandro Della Puppa; Renzo Manara; Diego Cecchin; Antonella Brunello; Alessandro Cappetta; Vittorina Zagonel |
Publication Detail:
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Type: Journal Article; Review Date: 2011-07-27 |
Journal Detail:
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Title: The oncologist Volume: 16 ISSN: 1549-490X ISO Abbreviation: Oncologist Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-29 Completed Date: 2012-02-01 Revised Date: 2012-04-25 |
Medline Journal Info:
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Nlm Unique ID: 9607837 Medline TA: Oncologist Country: United States |
Other Details:
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Languages: eng Pagination: 1175-88 Citation Subset: IM |
Affiliation:
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Medical Oncology 1 Unit, Istituto Oncologico Veneto–IRCCS, Padova, Italy. giuseppe.lombardi@ioveneto.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use Clinical Trials as Topic Humans Meningitis / diagnosis*, drug therapy*, etiology, radiotherapy Neoplasm Metastasis Neoplasms / cerebrospinal fluid, complications* Subarachnoid Space / pathology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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