Document Detail

Neoplasms following childhood radium irradiation of the nasopharynx.
MedLine Citation:
PMID:  6948125     Owner:  NLM     Status:  MEDLINE    
Eighteen to 35 years after admission to a clinic for the prevention of deafness, no increased overall cancer risk could be detected among 904 persons who had been treated with nasopharyngeal radium irradiation when compared with the risk among 2,021 persons who were either treated surgically or not treated at all, although there were differences at specific sites. An increased risk of developing both benign and malignant head and neck tumors was found among irradiated persons. Whereas no one head and neck site showed a statistically significant excess, a slight excess of brain cancer occurred 15-20 years after radium treatment. No increase in thyroid cancer risk was observed, a result possibly attributable to the low radiation doses to this organ, and the relatively small population irradiated.
D P Sandler; G W Comstock; G M Matanoski
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the National Cancer Institute     Volume:  68     ISSN:  0027-8874     ISO Abbreviation:  J. Natl. Cancer Inst.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-03-26     Completed Date:  1982-03-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503089     Medline TA:  J Natl Cancer Inst     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3-8     Citation Subset:  IM    
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MeSH Terms
Adenoids / pathology
Brachytherapy / adverse effects*
Child, Preschool
Follow-Up Studies
Head and Neck Neoplasms / etiology*
Hearing Loss / prevention & control
Nasopharynx / radiation effects
Neoplasms, Radiation-Induced / etiology*
Radium / adverse effects*
Grant Support
1-R01-FD00977/FD/FDA HHS; CA24758/CA/NCI NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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