Document Detail


Neonicotinoid insecticides: highlights of a symposium on strategic molecular designs.
MedLine Citation:
PMID:  21077684     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Neonicotinoids are the newest of the five major classes of insecticides (the others are chlorinated hydrocarbons, organophosphorus compounds, methylcarbamates, and pyrethroids), and they make up approximately one-fourth of the world insecticide market. Nithiazine was the lead compound from Shell Development Co. in California later optimized by Shinzo Kagabu of Nihon Tokushu Noyaku Seizo to increase the potency and photostability, resulting in imidacloprid and thiacloprid. These discoveries are the basis for the International Award for Research in Agrochemicals of the American Chemical Society presented in 2010 to Professor Shinzo Kagabu. Five other neonicotinoids were added by others for the current set of seven commercial compounds. This symposium considers the progress in discovery and development of novel chemotype nicotinic insecticides with enhanced effectiveness, unique biological properties, and maximal safety. Chemorational approaches considered include physicochemical properties, metabolic activation and detoxification, and chemical and structural biology aspects potentially facilitating receptor structure-guided insecticide design.
Authors:
Motohiro Tomizawa; John E Casida
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Publication Detail:
Type:  Journal Article     Date:  2010-11-15
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  59     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2883-6     Citation Subset:  IM    
Affiliation:
Faculty of Education, Gifu University , 1-1 Yanagido, Gifu 501-1193, Japan.
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