Document Detail

Neonates born from mothers with autoimmune disorders.
MedLine Citation:
PMID:  19765919     Owner:  NLM     Status:  MEDLINE    
Systemic autoimmune disorders have a higher prevalence in women, particularly during their childbearing age. A growing interest is being paid to the possible consequences of maternal disease and associated treatment on the fetus and newborn infant. If maternal disease is characterized by the presence of IgG isotype auto-antibodies, these can cross the placenta with possible antibody-mediated damage to the fetus. The risk of gestational complications, including preterm delivery, intrauterine growth retardation and low birth weight is higher in autoimmune diseases rather than in the general population and probably this finding is related to both maternal disorder and immunosuppressive therapy. Recently, results of our studies suggest that the antenatal exposure to immunosuppressive drugs given to mothers during pregnancy to treat autoimmune diseases does not impair significantly the development of immunity in exposed children. Finally, mothers disease and/or treatment could be related to neuropsychological dysfunctions reported in some of their children.
Mario Motta; Carmen Rodriguez-Perez; Angela Tincani; Andrea Lojacono; Renata Nacinovich; Gaetano Chirico
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Publication Detail:
Type:  Journal Article     Date:  2009-09-17
Journal Detail:
Title:  Early human development     Volume:  85     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-02     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  S67-70     Citation Subset:  IM    
Neonatal Intensive Care Unit, Children's Hospital of Brescia, Brescia, Italy.
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MeSH Terms
Antiphospholipid Syndrome / etiology
Autoimmune Diseases / complications*,  drug therapy
Fetal Growth Retardation / etiology
Follow-Up Studies
Immunosuppressive Agents / adverse effects*
Infant, Low Birth Weight
Infant, Newborn / growth & development,  immunology*
Lupus Erythematosus, Systemic / congenital
Maternal Exposure*
Maternal-Fetal Exchange
Pregnancy Complications / immunology*
Pregnancy Outcome
Premature Birth / etiology
Risk Factors
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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