| A neonate with long QT syndrome, refractory ventricular arrhythmias, and lidocaine toxicity. | |
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MedLine Citation:
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PMID: 22218697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long QT syndrome is characterized by electrocardiographic appearance of long QT intervals and propensity to polymorphic ventricular tachycardia. Aggressive anticipatory clinical management is required for a good outcome, especially in the symptomatic neonate. We present a neonate with a compound mutation with refractory ventricular tachycardia that necessitated multimodal pharmacotherapy with lidocaine, esmolol, and amiodarone along with ventricular pacing. Despite normal serum lidocaine levels, complex pharmacokinetic interactions resulted in presumed neurotoxicity due to lidocaine. This report discusses the implications and challenges of management of a neonate with compound long mutations. |
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Authors:
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Aruna T Nathan; Maryam Naim; Lisa M Montenegro; Victoria L Vetter |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2012-01-04 |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 114 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-23 Completed Date: 2012-03-08 Revised Date: 2012-12-20 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 407-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology & Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, USA. aruna.nathan@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amiodarone
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administration & dosage Anesthetics, Local / administration & dosage, adverse effects*, pharmacokinetics Anti-Arrhythmia Agents / administration & dosage, adverse effects*, pharmacokinetics Cardiac Pacing, Artificial DNA Mutational Analysis Drug Interactions Drug Substitution Drug Therapy, Combination Humans Infant, Newborn Lidocaine / administration & dosage, adverse effects*, pharmacokinetics Long QT Syndrome / diagnosis, drug therapy*, genetics Male Propanolamines / administration & dosage Tachycardia, Ventricular / diagnosis, drug therapy*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Anti-Arrhythmia Agents; 0/Propanolamines; 137-58-6/Lidocaine; 1951-25-3/Amiodarone; MDY902UXSR/esmolol |
| Comments/Corrections | |
Comment In:
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Anesth Analg. 2012 Nov;115(5):1253-4; author reply 1254
[PMID:
23093585
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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