Document Detail

Neonate characteristics after maternal use of antidepressants in late pregnancy.
MedLine Citation:
PMID:  15066868     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Exposure to antidepressants during the third trimester of pregnancy has been associated with an increased risk for adverse birth outcomes, including preterm birth, respiratory distress, and hypoglycemia. OBJECTIVE: To investigate neonatal outcomes in 997 infants (987 mothers) after maternal use of antidepressants based on prospectively recorded information in antenatal care documents. RESULTS: An increased risk for preterm birth (odds ratio [OR], 1.96) and low birth weight (OR, 1.98) was verified, but the gestational week-specific birth weight was increased notably after exposure to tricyclic antidepressants. An increased risk for a low Apgar score (OR, 2.33), respiratory distress (OR, 2.21), neonatal convulsions (OR,1.90), and hypoglycemia (OR, 1.62) was found, the latter especially after exposure to tricyclic drugs, but no significant effect on the frequency of neonatal jaundice was seen (OR, 1.13). Most effects seemed not to be selective serotonin reuptake inhibitor drug specific, and outcomes after exposure to paroxetine hydrochloride were not worse than after exposure to other selective serotonin reuptake inhibitors. CONCLUSIONS: Neonatal effects after maternal use of antidepressant drugs during late pregnancy were seen. Selective serotonin reuptake inhibitors may be the drugs of choice during pregnancy.
Bengt Källén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  158     ISSN:  1072-4710     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  312-6     Citation Subset:  AIM; IM    
Tornblad Institute, University of Lund, Lund, Sweden.
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MeSH Terms
Antidepressive Agents / adverse effects*
Apgar Score
Depressive Disorder / drug therapy*
Drug Therapy, Combination
Epilepsy, Benign Neonatal / chemically induced
Hypoglycemia / chemically induced
Infant, Low Birth Weight
Infant, Newborn
Middle Aged
Obstetric Labor, Premature / chemically induced
Odds Ratio
Pregnancy / psychology*
Prenatal Exposure Delayed Effects*
Prospective Studies
Respiratory Distress Syndrome, Newborn / chemically induced
Serotonin Uptake Inhibitors / adverse effects*
Smoking / epidemiology
Sweden / epidemiology
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors
Comment In:
Arch Pediatr Adolesc Med. 2004 Apr;158(4):307-8   [PMID:  15066865 ]

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