| Neonatal withdrawal syndrome after chronic maternal drinking of mate. | |
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MedLine Citation:
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PMID: 17304161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The premature newborn of a mother who reported drinking mate during pregnancy presented with increased jitteriness and irritability, high-pitched cry, hypertonia in the limbs, and brisk tendon reflexes consistent with neonatal withdrawal syndrome. High concentrations of caffeine and theobromine were detected in various maternal and neonatal biological matrices (placenta, cord serum, neonatal urine, maternal and neonatal hair, meconium, and breast milk), demonstrating both acute and chronic prenatal and postnatal exposure to these methylxanthines, contained in high amounts in homemade mate. Symptoms progressively disappeared at 84 hours of age, although intermittent irritability was still present when the infant was discharged at 24 days of age. Fluctuating caffeine (and theobromine) content in different breast milk feeds likely generated the baby's irritability, due to either the physiological stimulatory effects of the methylxanthines or postnatal withdrawal syndrome as the substances cleared from the body. The mother was strongly advised to initiate a considerable, progressive, constant reduction of mate consumption to a maximum of 2 cups a day for the duration of breastfeeding. |
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Authors:
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Itziar Martín; María Angeles López-Vílchez; Antonio Mur; Oscar García-Algar; Silvia Rossi; Emilia Marchei; Simona Pichini |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: 29 ISSN: 0163-4356 ISO Abbreviation: Ther Drug Monit Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-16 Completed Date: 2007-07-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: United States |
Other Details:
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Languages: eng Pagination: 127-9 Citation Subset: IM |
Affiliation:
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Neonatology Unit, Service of Pediatrics, Hospital Universitari del Mar, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Beverages
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adverse effects*,
analysis Breast Feeding / adverse effects Caffeine / analysis Female Humans Ilex paraguariensis / chemistry* Infant, Newborn Neonatal Abstinence Syndrome / etiology*, pathology Plant Extracts / chemistry Plant Leaves / chemistry Pregnancy Prenatal Exposure Delayed Effects* Theobromine / analysis |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 58-08-2/Caffeine; 83-67-0/Theobromine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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