Document Detail

Neonatal vitamin K might reduce vulnerability to alcohol dependence in Danish men.
MedLine Citation:
PMID:  16331844     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Levels of oxidative defenses and blood-clotting factors are normally reduced in newborns, increasing the risk of injury to developing brain structures around the time of birth. This early neonatal vulnerability corresponds to a timeframe in which the development of reward-related limbic structures is particularly active. Taking advantage of a serendipitous event in the history of treating newborns, we tested the hypothesis that vitamin K supplementation, administered to facilitate the synthesis of blood-clotting proteins within this critical timeframe, might also reduce the development of alcohol dependence later in life.
METHOD: Subjects were approximately full-term male infants, selected from a large Danish birth cohort. Two thirds of the original 330 subjects in this study were high-risk sons of alcoholic fathers; 241 of the total completed the 30-year follow-up. Of subjects reported on for this article (N = 238), 44 received vitamin K supplementation at birth; 161 were considered high risk, and 66 were categorized as having lower birth weight (<6 lbs). A comprehensive series of measures was obtained on each subject before, during and shortly after birth as well as at 1 year of age. The Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, diagnosis of alcohol dependence and a measure of lifetime problem drinking served as the 30-year outcome variables.
RESULTS: Vitamin K treatment, inherited risk and low birth weight each independently predicted alcohol dependence and problem drinking at age 30. Vitamin K treatment was associated with significantly lower rates of alcohol dependence and fewer symptoms of problem drinking.
CONCLUSIONS: Vitamin K treatment at birth might protect against the development of alcoholism in adults by reducing early postnatal hemorrhage and oxidative brain damage.
Ann M Manzardo; Elizabeth C Penick; Joachim Knop; Elizabeth J Nickel; Sandra Hall; Per Jensen; Cheryl C Miller; William F Gabrielli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of studies on alcohol     Volume:  66     ISSN:  0096-882X     ISO Abbreviation:  J. Stud. Alcohol     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-12-06     Completed Date:  2006-02-27     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7503813     Medline TA:  J Stud Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  586-92     Citation Subset:  IM    
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MeSH Terms
Alcoholism / genetics*,  prevention & control*
Blood Coagulation Factors / metabolism*
Brain Damage, Chronic / prevention & control
Cerebral Hemorrhage / prevention & control
Child of Impaired Parents / psychology
Child, Preschool
Cohort Studies
Follow-Up Studies
Infant, Low Birth Weight
Infant, Newborn
Infant, Newborn, Diseases / prevention & control*
Limbic System / drug effects
Oxidative Stress / drug effects
Vitamin K / administration & dosage*
Grant Support
GM063651/GM/NIGMS NIH HHS; R01-03448//PHS HHS; R01-08176//PHS HHS; R21-07539//PHS HHS; R21-13374//PHS HHS
Reg. No./Substance:
0/Blood Coagulation Factors; 12001-79-5/Vitamin K

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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