| Neonatal vitamin K might reduce vulnerability to alcohol dependence in Danish men. | |
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MedLine Citation:
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PMID: 16331844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Levels of oxidative defenses and blood-clotting factors are normally reduced in newborns, increasing the risk of injury to developing brain structures around the time of birth. This early neonatal vulnerability corresponds to a timeframe in which the development of reward-related limbic structures is particularly active. Taking advantage of a serendipitous event in the history of treating newborns, we tested the hypothesis that vitamin K supplementation, administered to facilitate the synthesis of blood-clotting proteins within this critical timeframe, might also reduce the development of alcohol dependence later in life. METHOD: Subjects were approximately full-term male infants, selected from a large Danish birth cohort. Two thirds of the original 330 subjects in this study were high-risk sons of alcoholic fathers; 241 of the total completed the 30-year follow-up. Of subjects reported on for this article (N = 238), 44 received vitamin K supplementation at birth; 161 were considered high risk, and 66 were categorized as having lower birth weight (<6 lbs). A comprehensive series of measures was obtained on each subject before, during and shortly after birth as well as at 1 year of age. The Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, diagnosis of alcohol dependence and a measure of lifetime problem drinking served as the 30-year outcome variables. RESULTS: Vitamin K treatment, inherited risk and low birth weight each independently predicted alcohol dependence and problem drinking at age 30. Vitamin K treatment was associated with significantly lower rates of alcohol dependence and fewer symptoms of problem drinking. CONCLUSIONS: Vitamin K treatment at birth might protect against the development of alcoholism in adults by reducing early postnatal hemorrhage and oxidative brain damage. |
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Authors:
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Ann M Manzardo; Elizabeth C Penick; Joachim Knop; Elizabeth J Nickel; Sandra Hall; Per Jensen; Cheryl C Miller; William F Gabrielli |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of studies on alcohol Volume: 66 ISSN: 0096-882X ISO Abbreviation: J. Stud. Alcohol Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-12-06 Completed Date: 2006-02-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7503813 Medline TA: J Stud Alcohol Country: United States |
Other Details:
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Languages: eng Pagination: 586-92 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, University of Kansas Medical Center, Kansas City 66160, USA. amanzardo@kumc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alcoholism / genetics*, prevention & control* Blood Coagulation Factors / metabolism* Brain Damage, Chronic / prevention & control Cerebral Hemorrhage / prevention & control Child Child of Impaired Parents / psychology Child, Preschool Cohort Studies Denmark Follow-Up Studies Humans Infant Infant, Low Birth Weight Infant, Newborn Infant, Newborn, Diseases / prevention & control* Limbic System / drug effects Male Oxidative Stress / drug effects Reward Risk Vitamin K / administration & dosage* |
| Grant Support | |
ID/Acronym/Agency:
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GM063651/GM/NIGMS NIH HHS; R01-03448//PHS HHS; R01-08176//PHS HHS; R21-07539//PHS HHS; R21-13374//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Coagulation Factors; 12001-79-5/Vitamin K |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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