| Neonatal type of nonketotic hyperglycinemia. | |
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MedLine Citation:
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PMID: 10328279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two infants with the neonatal type of nonketotic hyperglycinemia that had manifested as early neonatal consciousness disturbance are presented. Transient hyperammonemia had been detected in both initially. High levels of glycine in plasma and cerebrospinal fluid disturb the nervous system, causing variable manifestations of this disease. Both cases were complicated by intracranial hemorrhage, which has never before been reported. After treatment with sodium benzoate and dextromethorphan, some neurologic improvement was observed, although the glycine levels did not lower. Recent clinical trials are reviewed, and because of the unfavorable outcomes, the special need for prenatal diagnosis is highlighted. |
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Authors:
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F L Lu; P J Wang; W L Hwu; K I Tsou Yau; T R Wang |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 20 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-06-29 Completed Date: 1999-06-29 Revised Date: 2006-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 295-300 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, National Taiwan University Hospital, Taipei, ROC. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ammonia
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blood Brain / pathology Female Glycine / blood*, cerebrospinal fluid Humans Infant, Newborn Lactic Acid / blood Magnetic Resonance Imaging Male Metabolism, Inborn Errors / blood, cerebrospinal fluid, diagnosis*, therapy Muscle Hypotonia / diagnosis Psychomotor Disorders / diagnosis, rehabilitation Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 56-40-6/Glycine; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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