| Neonatal transient respiratory depression after maternal urapidil infusion for hypertension. | |
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MedLine Citation:
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PMID: 18461359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urapidil is a potent antihypertensive drug that has been in clinical use for more than 20 years. It has been proven to be an effective and well-tolerated antihypertensive drug during pregnancy, but clinical experiences with urapidil have been described in only a limited number of studies. There have also been only limited observations on the (side-)effects of urapidil on the neonate. We describe here a case of postnatal transient respiratory depression following maternal administration of urapidil. We suggest that the fetal and neonatal effects of more recently implemented antihypertensive drugs, such as urapidil, should be included in a prospective evaluation of antihypertensive treatment of women during pregnancy. Infants of mothers who received urapidil should be carefully watched in the immediate postnatal phase as urapidil may still exert some significant effects on the neonate. |
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Authors:
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Sophie Vanhaesebrouck; Myriam Hanssens; Karel Allegaert |
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Publication Detail:
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Type: Journal Article Date: 2008-05-07 |
Journal Detail:
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Title: European journal of pediatrics Volume: 168 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
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Languages: eng Pagination: 221-3 Citation Subset: IM |
Affiliation:
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Neonatal Intensive Care Unit, Division Woman and Child, University Hospitals-campus Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. sophie.vanhaesebrouck@uz.kuleuven.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / administration & dosage, adverse effects*, pharmacokinetics Cesarean Section Dose-Response Relationship, Drug Female Humans Hypertension / drug therapy* Infant, Newborn Infusions, Intravenous Male Piperazines / administration & dosage, adverse effects*, pharmacokinetics Pregnancy Pregnancy Complications, Cardiovascular / drug therapy* Respiratory Distress Syndrome, Newborn / chemically induced*, diagnosis, urine |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Piperazines; 34661-75-1/urapidil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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