Document Detail

Neonatal total IgE and respiratory tract infections in children with intrauterine smoke exposure.
MedLine Citation:
PMID:  20403828     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Exposure to environmental tobacco smoke (ETS) is known to increase the risk of respiratory tract infections (RTI). Some children, however, may be more susceptible to the harmful effects of ETS than others. We examined whether early atopic status (defined by elevated neonatal total IgE (tIgE) or symptoms of atopic dermatitis) modified the association between ETS exposure and RTI. METHODS: The data of 2863 children from the Prevention and Incidence of Asthma and Mite Allergy birth cohort were collected to the age of 4 years. Neonatal tIgE was collected from a subset of 914 children, and clinical information by yearly parental questionnaires. The effect of pre- and/or postnatal ETS exposure, early atopic status and interaction between these factors was studied for various RTI. RESULTS: Children with elevated tIgE or atopic dermatitis and prenatal ETS exposure have a strongly increased risk of frequent RTI (aOR 6.18 (95% CI 1.45 to 26.34) and 5.69 (2.01 to 16.04), respectively; interaction p=0.006 and p=0.14, respectively) compared to non-atopic children without prenatal ETS exposure. Similar results were seen for lower RTI and otitis. This effect was less evident for postnatal ETS. CONCLUSION: Early atopic status enhances the risk of RTI in children with prenatal ETS exposure. This suggests that host factors modify the association between ETS and RTI.
Jopje Ruskamp; Henriette Smit; Maroeska Rovers; Maarten Hoekstra; Anne Schilder; Bert Brunekreef; Alet Wijga; Marjan Kerkhof; Johan de Jongste; Elisabeth Sanders
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-04-19
Journal Detail:
Title:  Archives of disease in childhood     Volume:  95     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-08-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  England    
Other Details:
Languages:  eng     Pagination:  427-31     Citation Subset:  AIM; IM    
Department of Paediatrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands.
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MeSH Terms
Child, Preschool
Cohort Studies
Dermatitis, Atopic / complications,  epidemiology
Immunoglobulin E / blood*
Infant, Newborn
Netherlands / epidemiology
Prenatal Exposure Delayed Effects / epidemiology*
Respiratory Tract Infections / epidemiology,  etiology*,  immunology
Tobacco Smoke Pollution / adverse effects*,  analysis
Reg. No./Substance:
0/Tobacco Smoke Pollution; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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