Document Detail

Neonatal tolerance induction to Mlsa. I. Tolerance to Mlsa is restricted by shared MHC determinants.
MedLine Citation:
PMID:  2972396     Owner:  NLM     Status:  MEDLINE    
In this paper we have examined the influence of MHC (major histocompatibility complex) on neonatal tolerance to Mlsa (minor lymphocyte stimulating). By employing a novel approach we have shown that tolerance to Mlsa is restricted by shared MHC determinants. Thus, neonatal Mlsb mice, injected at birth with spleen cells from Mlsa mice, were tested as adults for Mlsa specific responses by interleukin-2 limiting dilution analysis, a technique which allows us to discriminate between responses to MHC + Mlsa and to MHC alone. Tolerance to Mlsa was in the context of any MHC type examined--donor, host, and third-party MHC products. These results show that tolerance to Mlsa is restricted by shared MHC determinants and extend previous studies indicating that activation of Mlsa responses is similarly restricted.
D J Waite; R A Miller; G H Sunshine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cellular immunology     Volume:  117     ISSN:  0008-8749     ISO Abbreviation:  Cell. Immunol.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-14     Completed Date:  1988-12-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  70-7     Citation Subset:  IM    
Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts.
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MeSH Terms
Animals, Newborn / immunology*
Immune Tolerance*
Interleukin-2 / pharmacology
Lymphocyte Culture Test, Mixed
Major Histocompatibility Complex*
Mice, Inbred Strains / immunology*
Minor Histocompatibility Loci*
Spleen / immunology
Grant Support
Reg. No./Substance:

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