Document Detail


Neonatal thyroid screening results are related to gestational maternal thyroid function.
MedLine Citation:
PMID:  21521349     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
  Objective:  To study the relationship between maternal thyroid function at each pregnancy trimester and neonatal screening results. Background: Overt maternal thyroid dysfunction during gestation is associated with poor neonatal thyroid function. However, research on the relationship between suboptimal maternal thyroid function (assessed at 3 trimesters) and neonatal thyroid screening outcome is scarce. Design/Patients:  Prospective follow-up study during three trimesters of gestation in 886 Dutch Caucasian healthy pregnant women followed from 12 weeks gestation until term delivery (> 37 weeks) and their neonates. Measurements:  The relation between neonatal data from the Congenital Hypothyroidism (CH) screening and maternal thyroid determinants (TSH, FT4 and TPO-Ab) assessed at 12, 24 and 36 weeks gestation. Results:  Boys have lower screening TT4 levels and their mothers have higher TSH levels at 24 and 36 weeks gestation. Higher maternal TSH levels (> 97.5th percentile, as defined in 810 women without TPO-Ab at 12 weeks) at one or more times during pregnancy (O.R: 2.26, 95% CI: 1.20 - 4.29). and lower gestational age (O.R : 1.22, 95% CI: 1.05 - 1.41) are independently related to lower screening TT4 levels Conclusions:  Maternal thyroid function during gestation is related to neonatal TT4 at screening. The finding of both lower neonatal TT4 levels in boys and higher TSH levels in mothers carrying boys is worthy of further investigation, as both observations may be meaningfully related.
Authors:
S M I Kuppens; L Kooistra; H A Wijnen; H L Vader; T H M Hasaart; S G Oei; T Vulsma; V J Pop
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-25
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Affiliation:
Dept. of Obstetrics & Gynecology, Catharina Hospital, Eindhoven, the Netherlands. Dept. of Primary Care, University of Tilburg, the Netherlands. Dept. of Pediatrics, Alberta Children's Hospital, University of Calgary, Canada. Dept. of Midwifery Science, AVM University, Maastricht, the Netherlands. Dept. of Clinical Chemistry, Máxima Medical Centre, Eindhoven, the Netherlands. Dept. of Obstetrics & Gynecology, Máxima Medical Centre, Eindhoven, the Netherlands. Dept. of Electrical Engineering, University of Technology, Eindhoven, the Netherlands. Dept of Pediatrics, Emma Childrens's Hospital, Amsterdam, The Netherlands.
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