Document Detail

Neonatal thyroid function: prematurity, prenatal steroids, and respiratory distress syndrome.
MedLine Citation:
PMID:  3729529     Owner:  NLM     Status:  MEDLINE    
Indices of thyroid function were measured in 97 preterm infants at birth and at 5, 10, and 15 days of age. Triiodothyronine uptake, free thyroxine index, thyroxine, free thyroxine, triiodothyronine, reverse triiodothyronine, and thyroxine binding globulin values at birth correlated with gestational age, whereas thyroid stimulating hormone values did not. Treatment with steroids prenatally had no apparent effect on thyroid function at birth or postnatally. Infants developing respiratory distress syndrome had normal values for all indices at birth. These infants had significantly lower thyroxine, free thyroxine index, free thyroxine, and triiodothyronine values at 5 days of age, while thyroid stimulating hormone values remained normal. This alteration in thyroid function was interpreted as being secondary to respiratory distress syndrome. Gestational maturity and respiratory distress syndrome, if present, must be taken into account when evaluating thyroxine variables in preterm infants, whereas measurement of thyroid stimulating hormone as the screen for congenital hypothyroidism circumvents these considerations.
R C Franklin; G L Purdie; C M O'Grady
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  61     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-08-13     Completed Date:  1986-08-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  589-92     Citation Subset:  AIM; IM    
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MeSH Terms
Birth Weight
Gestational Age
Glucocorticoids / pharmacology*
Infant, Newborn
Infant, Premature*
Longitudinal Studies
New Zealand
Respiratory Distress Syndrome, Newborn / physiopathology*
Thyroid Gland / drug effects,  physiology,  physiopathology*
Thyroid Hormones / blood
Reg. No./Substance:
0/Glucocorticoids; 0/Thyroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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