Document Detail


Neonatal tactile stimulation enhances spatial working memory, prefrontal long-term potentiation, and D1 receptor activation in adult rats.
MedLine Citation:
PMID:  18077190     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Environmental stimuli during neonatal periods play an important role in the development of cognitive function. In this study, we examined the long-term effects of neonatal tactile stimulation (TS) on spatial working memory (SWM) and related mechanisms. We also investigated whether TS-induced effects could be counteracted by repeated short periods of maternal separation (MS). Wistar rat pups submitted to TS were handled and marked transiently per day during postnatal days 2-9 or 10-17. TS/MS pups were stimulated in the same way as TS pups and then individually separated from their mother for 1h/day. Their nontactile stimulated (NTS) siblings served as controls. In adulthood, TS and TS/MS rats showed better performance in two versions of the delayed alternation task and superior in vivo long-term potentiation of the hippocampo-prefrontal cortical pathway when compared with controls. Furthermore, there were more doses of A77636 (a selective dopamine D1 agonist) to significantly improve SWM performance in TS and TS/MS rats than in NTS rats, suggesting that activation of prefrontal D1 receptors in TS and TS/MS rats is more optimal for SWM function than in NTS rats. MS did not counteract TS-induced effects because no significant difference was found between TS/MS and TS animals. These data indicate that in early life, external tactile stimulation leads to long-term facilitative effects in SWM-related neural function.
Authors:
Ming Zhang; Jing-Xia Cai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-20
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  89     ISSN:  1095-9564     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-14     Completed Date:  2008-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-406     Citation Subset:  IM    
Affiliation:
Division of Brain and Behavior, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang East Road, Kunming, Yunnan 650223, China.
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MeSH Terms
Descriptor/Qualifier:
Adamantane / analogs & derivatives,  pharmacology
Age Factors
Animals
Animals, Newborn
Benzopyrans / pharmacology
Body Weight
Discrimination Learning / drug effects,  physiology
Dopamine Agonists / pharmacology
Environment
Female
Habituation, Psychophysiologic / drug effects,  physiology
Long-Term Potentiation / drug effects,  physiology*
Male
Maternal Deprivation
Memory, Short-Term / drug effects,  physiology*
Neuronal Plasticity / drug effects,  physiology
Prefrontal Cortex / growth & development,  physiology*
Pregnancy
Rats
Rats, Wistar
Receptors, Dopamine D1 / agonists,  physiology*
Space Perception / drug effects,  physiology*
Touch / physiology*
Chemical
Reg. No./Substance:
0/Benzopyrans; 0/Dopamine Agonists; 0/Receptors, Dopamine D1; 145307-34-2/A 77636; 281-23-2/Adamantane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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