Document Detail

Neonatal susceptibility and immunity to major bacterial pathogens.
MedLine Citation:
PMID:  2194266     Owner:  NLM     Status:  MEDLINE    
Neonatal bacterial sepsis has continued in this decade to contribute significantly to neonatal mortality and morbidity and is a critical determinant of outcome in infants of very low birth weight despite the availability of antibiotics. The group B Streptococcus and Escherichia coli are the predominant pathogens for the newborn infant. Studies on the epidemiology, microbiology, and immunology of group B streptococcal disease are more extensive than those on E. coli disease. Type-specific antibodies, polymorphonuclear leukocytes, and complement are integral to immunity against group B Streptococcus, and experimental data are presented to support the importance of these components. The newborn infant is handicapped by temporary deficiencies in host defenses, and approaches for restoring immunocompetence, such as immunization of the mother or passive administration of intravenous immunoglobulins or other immune factors, are presented for consideration. Further studies are required to demonstrate the safety, feasibility, and efficacy of these approaches.
P Ferrieri
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  12 Suppl 4     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1990 May-Jun
Date Detail:
Created Date:  1990-08-08     Completed Date:  1990-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S394-400     Citation Subset:  IM    
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis 55455.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Bacterial Infections / epidemiology,  immunology*,  prevention & control
Disease Susceptibility
Escherichia coli Infections / epidemiology,  immunology,  prevention & control
Immunization, Passive
Infant, Newborn
Meningitis / epidemiology,  immunology,  prevention & control
Streptococcal Infections / epidemiology,  immunology,  prevention & control
Streptococcus agalactiae
Grant Support
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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