Document Detail


Neonatal sex hormones have 'organizational' effects on the hypothalamic-pituitary-adrenal axis of male rats.
MedLine Citation:
PMID:  9541747     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sex hormones have activational effects on the hypothalamic-pituitary-adrenal (HPA) axis in adulthood: For example, corticosterone release is influenced by gonadal status. These experiments investigated whether sex hormones have organizational effects on the HPA axis of male rats: Do sex hormones have relatively permanent effects on its development? In adults, both neonatal (neoGDX) and adult gonadectomy (adult GDX) resulted in elevated corticosterone (CORT) levels in response to stress compared to intact rats. Five days of testosterone propionate (TP) replacement was not as effective at attenuating CORT levels in neoGDX rats as in adult GDX rats. Neonatal GDX elevated corticosterone binding globulin (CBG) levels, whereas adult GDX was without effect. In Experiment 2 the effects of neonatal gonadectomy and neonatal treatment with either TP, estradiol benzoate (EB), or oil vehicle was examined. Despite 14 days of hormone replacement, neoGDX showed elevated CORT levels in response to stress compared to all other groups. A single neonatal dose of TP or EB in neoGDX rats eliminated the increased responsiveness. Neonatal TP and EB were without effect in sham-operated rats. Plasma CBG levels were elevated in neoGDX groups regardless of neonatal hormone treatment. Corticosteroid receptor binding levels were examined in various brain areas and the pituitary in two groups most different in their androgen experience: NeoGDX and shams that did not receive treatments as adults. NeoGDX had lower levels of glucocorticoid receptor, and higher levels of mineralocorticoid receptor binding in the pituitary. No other receptor differences were found. These experiments suggest that neonatal sex hormones influence the sensitivity of the HPA axis to sex hormones in adulthood and, thus, that they have organizational effects in addition to activational effects on HPA function.
Authors:
C M McCormick; B F Furey; M Child; M J Sawyer; S M Donohue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  105     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  295-307     Citation Subset:  IM    
Affiliation:
Neuroscience Program, Bates College, Lewiston, Maine 04240, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Corticosterone / blood
Estrogens / pharmacology
Gonadal Steroid Hormones / pharmacology,  physiology*
Hypothalamo-Hypophyseal System / growth & development,  physiology*
Male
Orchiectomy
Pituitary-Adrenal System / growth & development,  physiology*
Rats
Receptors, Steroid / metabolism
Sex Differentiation
Stress, Psychological / metabolism
Testosterone / pharmacology
Transcortin / metabolism
Chemical
Reg. No./Substance:
0/Estrogens; 0/Gonadal Steroid Hormones; 0/Receptors, Steroid; 50-22-6/Corticosterone; 58-22-0/Testosterone; 9010-38-2/Transcortin

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