Document Detail

Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats.
MedLine Citation:
PMID:  22661175     Owner:  NLM     Status:  In-Data-Review    
Background: Extensive previous research has suggested a role for serotonin (5-HT) in learning and memory processes, both in healthy individuals and pathological disorders including depression, autism and schizophrenia, most of which have a developmental onset. Since 5-HT dysfunction in brain development may be involved in disease etiology, the present investigation assessed the effects of neonatal 5-HT depletion on spatial learning and memory in the Morris water maze (MWM). Methods: Three days old Sprague-Dawley rats were pretreated with desipramine (20 mg/kg) followed by an intraventricular injection of the selective 5-HT neurotoxin 5,7-dihydroxytryptamine (5,7-DHT, 70 μg). Three months later rats were tested in the MWM. Results: Despite a severe and permanent decrease (80-98%) in hippocampal, prefrontal and striatal 5-HT levels, treatment with 5,7-DHT caused no spatial learning and memory impairment. Conclusions: Limited involvement of chronic 5-HT depletion on learning and memory does not exclude the possibility that this neurotransmitter has an important neuromodulatory role in these functions. Future studies will be needed to identify the nature of the compensatory processes that are able to allow normal proficiency of spatial learning and memory in 5-HT-depleted rats.
Agnieszka Piechal; Kamilla Blecharz-Klin; Edyta Wyszogrodzka; Paulina Kołomańska; Paulina Rok-Bujko; Paweł Krząścik; Wojciech Kostowski; Ewa Widy-Tyszkiewicz; Małgorzata Filip; Roman Stefański
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  64     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  266-74     Citation Subset:  IM    
Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Krakowskie Przedmieście 26/28, PL 00-927 Warszawa, Poland.
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