Document Detail

Neonatal sensorineural hearing loss associated with furosemide: a case-control study.
MedLine Citation:
PMID:  1936634     Owner:  NLM     Status:  MEDLINE    
Thirty-five neonates with sensorineural hearing loss (SNHL), identified by brainstem auditory evoked response (BAER), and 70 matched controls with normal BAERs were studied. All infants had had BAERs before discharge from hospital as part of a screening program for high-risk neonates. Infants with SNHL showed no response to a 60dBnHL click stimulus and all had these results confirmed on at least one occasion after hospital discharge. Based on the screening program results, over-all prevalence of non-hereditary hearing loss was estimated to be 0.93 per 1000 live births, and in neonates weighing less than 2000g at birth to be 15.54 per 1000 live births. Several factors, including seizures, exposure to anticonvulsant drugs, furosemide and kanamycin were associated with SNHL, but after multivariate analysis, only exposure to furosemide remained significant. Peak serum bilirubin concentration and benzyl alcohol exposure did not appear to be related to hearing loss.
D R Brown; J F Watchko; D Sabo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  33     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1991-12-06     Completed Date:  1991-12-06     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  816-23     Citation Subset:  IM    
Department of Pediatrics, University of Pittsburgh Medical School, PA.
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MeSH Terms
Auditory Threshold / drug effects
Brain Stem / drug effects
Child, Preschool
Deafness / chemically induced,  diagnosis
Evoked Potentials, Auditory, Brain Stem / drug effects
Follow-Up Studies
Furosemide / administration & dosage,  adverse effects*
Hearing Loss, Sensorineural / chemically induced*,  diagnosis
Infant, Newborn
Infant, Premature, Diseases / drug therapy*
Intensive Care Units, Neonatal
Risk Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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