Document Detail


Neonatal seizures: treatment practices among term and preterm infants.
MedLine Citation:
PMID:  22264706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal seizures are common clinical conditions in both term and preterm neonates, yet no clinical management guidelines for direct care exist. We surveyed 193 international neurologists, neonatologists, and specialists in neonatal neurology or neonatal neurocritical care to assess management practices for seizures in preterm and term neonates. We found high reported rates of electroencephalogram and amplitude-integrated electroencephalogram (aEEG) monitoring to detect neonatal seizures, prevalent use of older anticonvulsant agents, and high rates of neuroimaging. Overall, responses were similar for term and preterm neonates. However, term neonates were likelier to be more heavily investigated, with higher use of magnetic resonance imaging and of electroencephalogram and aEEG monitoring of at-risk neonates. Continuous monitoring and cranial imaging of neonatal seizures now comprise the standard of care in many centers, although management practices vary widely. Early recognition and management of neonatal seizures and possible underlying injury may lead to increased opportunities for stopping seizures, protecting the brain, and improving developmental outcomes in at-risk neonates. The need for collaboration among neonatologists and neurologists is urgent, to address gaps in knowledge regarding management of neonatal seizures in term and preterm neonates.
Authors:
Hannah C Glass; Jessica Kan; Sonia L Bonifacio; Donna M Ferriero
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatric neurology     Volume:  46     ISSN:  1873-5150     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-06-04     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / therapeutic use
Electroencephalography
Female
Humans
Infant
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging
Male
Monitoring, Physiologic
Physician's Practice Patterns*
Questionnaires
Seizures / diagnosis*,  drug therapy
Grant Support
ID/Acronym/Agency:
K23 NS066137/NS/NINDS NIH HHS; K23 NS066137-01A1/NS/NINDS NIH HHS; K23NS66137/NS/NINDS NIH HHS; KL2 RR024130/RR/NCRR NIH HHS; KL2 RR024130/RR/NCRR NIH HHS; KL2 RR024130-01/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants
Comments/Corrections

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