Document Detail


Neonatal seizures and status epilepticus.
MedLine Citation:
PMID:  23027101     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal seizures are common, often require EEG monitoring for diagnosis and management, may be associated with worse neurodevelopmental outcome, and can often be treated with existing anticonvulsants. A neonatal electrographic seizure is defined as a sudden, repetitive, evolving, and stereotyped event of abnormal electrographic pattern with amplitude of at least 2 μV and a minimum duration of 10 seconds. The diagnosis of neonatal seizures relies heavily on the neurophysiologist's interpretation of EEG. Consideration of specific criteria for the definition of a neonatal seizure, including seizure duration, location, morphology, evolution, semiology, and overall seizure burden, has utility for both the clinician and the researcher. The importance of EEG in the diagnosis and management of neonatal seizures, the electrographic characteristics of neonatal seizures, the impact of neonatal seizures on outcome, and tools to aid in the identification of neonatal seizures are reviewed.
Authors:
Nicholas S Abend; Courtney J Wusthoff
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  29     ISSN:  1537-1603     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-03-05     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-8     Citation Subset:  IM    
Affiliation:
Division of Neurology, The Children's Hospital of Philadelphia, the Departments of Neurology and Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA. abend@email.chop.edu
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / therapeutic use
Brain / drug effects,  physiopathology*
Brain Mapping / methods*
Brain Waves* / drug effects
Electroencephalography*
Humans
Infant, Newborn
Periodicity
Predictive Value of Tests
Spasms, Infantile / diagnosis*,  drug therapy,  physiopathology
Status Epilepticus / diagnosis*,  drug therapy,  physiopathology
Time Factors
Treatment Outcome
Grant Support
ID/Acronym/Agency:
K23 NS076550/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants
Comments/Corrections

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