| Neonatal seizures and post-neonatal epilepsy: a seven-year follow-up study. | |
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MedLine Citation:
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PMID: 22580721 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND:Seizures are one of the most common symptoms of acute neurological disorders in newborns. This study aims at evaluating predictors of epilepsy in newborns with neonatal seizures.METHODS:we recruited consecutively eighty-five neonates with repeated neonatal video-EEG-confirmed seizures between Jan 1999 and Dec 2004. The relationship between clinical, EEG and ultrasound data in neonatal period and the development of post-neonatal epilepsy was investigated at 7 years of age.RESULTS:Fifteen patients (17.6%) developed post-neonatal epilepsy. Partial or no response to anticonvulsant therapy (OR 16.7, 95% CI: 1.8-155.8, p= .01; OR 47, 95% CI: 5.2-418.1, p< .01 respectively), severely abnormal cerebral ultrasound scan findings (OR: 5.4; 95% CI: 1.1-27.4; p< .04), severely abnormal EEG background activity (OR: 9.5; 95% CI: 1.6-54.2; p= .01) and the presence of status epilepticus (OR: 6.1; 95% CI: 1.8-20.3; p< .01) were found to be predictors of epilepsy. However, only the response to therapy seemed to be an independent predictor of post-neonatal epilepsy.CONCLUSION:Neonatal seizures seem to be related to post-neonatal epilepsy. Recurrent and prolonged neonatal seizures may act on an epileptogenic substrate, causing further damage, which is responsible for the subsequent clinical expression of epilepsy. |
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Authors:
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Francesco Pisani; Benedetta Piccolo; Gaetano Cantalupo; Cristiana Copioli; Carlo Fusco; Annalisa Pelosi; Carlo Alberto Tassinari; Stefano Seri |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-11 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Child Neuropsychiatric Unit, Department of Gynecology, Obstetrics and Neonatology, University-Hospital of Parma, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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