Document Detail

Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy.
MedLine Citation:
PMID:  16199350     Owner:  NLM     Status:  MEDLINE    
This is the first report of a neonatal withdrawal syndrome associated with maternal hydroxyzine treatment (150 mg/day) confirmed by measurements of hydroxyzine plasma concentrations in the mother and infant after birth. Hydroxyzine plasma concentrations were measured by liquid chromatography-mass spectrometry. Neurological symptoms with low neonatal concentrations of hydroxyzine may be due to a withdrawal syndrome. According to previous observations and this case report, clinicians should be warned of this possible rare neurological complication of hydroxyzine in neonates born from long term treated mothers.
Raphaël Serreau; Meriem Komiha; Florence Blanc; François Guillot; Evelyne Jacqz-Aigrain
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-04-15
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  20     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2005 Nov-Dec
Date Detail:
Created Date:  2005-10-03     Completed Date:  2006-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  573-4     Citation Subset:  IM    
Paediatric Pharmacology and Pharmacogenetic, Hôpital Robert debré, 48 boulevard Sérurier, Paris, France.
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MeSH Terms
Fetal Blood / chemistry
Histamine H1 Antagonists / administration & dosage,  adverse effects*,  blood
Hydroxyzine / administration & dosage,  adverse effects*,  blood
Infant, Newborn
Infant, Newborn, Diseases / chemically induced*
Maternal-Fetal Exchange
Seizures / chemically induced*
Substance Withdrawal Syndrome / etiology*
Reg. No./Substance:
0/Histamine H1 Antagonists; 68-88-2/Hydroxyzine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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