| Neonatal seizures associated with maternal hydroxyzine hydrochloride in late pregnancy. | |
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MedLine Citation:
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PMID: 16199350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This is the first report of a neonatal withdrawal syndrome associated with maternal hydroxyzine treatment (150 mg/day) confirmed by measurements of hydroxyzine plasma concentrations in the mother and infant after birth. Hydroxyzine plasma concentrations were measured by liquid chromatography-mass spectrometry. Neurological symptoms with low neonatal concentrations of hydroxyzine may be due to a withdrawal syndrome. According to previous observations and this case report, clinicians should be warned of this possible rare neurological complication of hydroxyzine in neonates born from long term treated mothers. |
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Authors:
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Raphaël Serreau; Meriem Komiha; Florence Blanc; François Guillot; Evelyne Jacqz-Aigrain |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2005-04-15 |
Journal Detail:
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Title: Reproductive toxicology (Elmsford, N.Y.) Volume: 20 ISSN: 0890-6238 ISO Abbreviation: Reprod. Toxicol. Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2005-10-03 Completed Date: 2006-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803591 Medline TA: Reprod Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 573-4 Citation Subset: IM |
Affiliation:
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Paediatric Pharmacology and Pharmacogenetic, Hôpital Robert debré, 48 boulevard Sérurier, Paris, France. raphael.serreau@rdb.aphp.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Blood / chemistry Histamine H1 Antagonists / administration & dosage, adverse effects*, blood Humans Hydroxyzine / administration & dosage, adverse effects*, blood Infant, Newborn Infant, Newborn, Diseases / chemically induced* Male Maternal-Fetal Exchange Pregnancy Seizures / chemically induced* Substance Withdrawal Syndrome / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Histamine H1 Antagonists; 68-88-2/Hydroxyzine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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