Document Detail


Neonatal seizures: Dialogues between clinic and bench.
MedLine Citation:
PMID:  22656393     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Neonatal seizures are common and often reflect a severe underlying neurologic dysfunction in neonates. Phenobarbital remains the mainstay of treatment of neonatal seizures, however, but it is ineffective in many patients and has adverse profiles in cognition. Furthermore, gamma-aminobutyric acid is excitatory early in brain development; therefore, treatment of neonatal seizures with phenobarbital must be cautious. In this review, we highlight the substantial progress that has been made in animal studies, and translate these results to the treatment of seizures in human neonates.
Authors:
Li-Tung Huang; You-Lin Tain; Ming-Chi Lai; San-Nan Yang
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Publication Detail:
Type:  Journal Article     Date:  2012-04-07
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  111     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-06-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Pediatrics, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University, College of Medicine, Taiwan.
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