Document Detail

Neonatal screening for congenital hypothyroidism in Estonia.
MedLine Citation:
PMID:  9575454     Owner:  NLM     Status:  MEDLINE    
Screening for congenital hypothyroidism was carried out by measuring thyroid stimulating hormone (TSH) on dried blood spots (mean + 2SD cut off value 12 microU/ml) by fluoroimmunoassay using DELFIA kits. A total of 20,021 infants were screened, and seven cases with congenital hypothyroidism were detected, giving an incidence of congenital hypothyroidism of 1:2860 (female:male ratio 6:1). In four of seven infants with congenital hypothyroidism (57%) the mother also had thyroid disease, supporting the importance of genetic factors as a cause of congenital hypothyroidism. Transient hyperthyrotropinaemia occurred in 654 infants (recall rate 3.3%). There was a significant association of transient hyperthyrotropinaemia only with cardiac failure at birth or caesarean section (p < 0.01). Family studies showed no predisposition to thyroid diseases associated with a transient increase of TSH.
R V Mikelsaar; R Zordania; M Viikmaa; G Kudrjavtseva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical screening     Volume:  5     ISSN:  0969-1413     ISO Abbreviation:  J Med Screen     Publication Date:  1998  
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9433359     Medline TA:  J Med Screen     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  20-1     Citation Subset:  IM    
Department of Human Biology and Genetics, University of Tartu, Estonia.
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MeSH Terms
Congenital Hypothyroidism*
Estonia / epidemiology
Hypothyroidism / diagnosis*,  epidemiology
Infant, Newborn
Neonatal Screening*
Thyroid Hormones / analysis
Reg. No./Substance:
0/Thyroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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