| Neonatal screening for congenital hypothyroidism in Estonia. | |
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MedLine Citation:
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PMID: 9575454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Screening for congenital hypothyroidism was carried out by measuring thyroid stimulating hormone (TSH) on dried blood spots (mean + 2SD cut off value 12 microU/ml) by fluoroimmunoassay using DELFIA kits. A total of 20,021 infants were screened, and seven cases with congenital hypothyroidism were detected, giving an incidence of congenital hypothyroidism of 1:2860 (female:male ratio 6:1). In four of seven infants with congenital hypothyroidism (57%) the mother also had thyroid disease, supporting the importance of genetic factors as a cause of congenital hypothyroidism. Transient hyperthyrotropinaemia occurred in 654 infants (recall rate 3.3%). There was a significant association of transient hyperthyrotropinaemia only with cardiac failure at birth or caesarean section (p < 0.01). Family studies showed no predisposition to thyroid diseases associated with a transient increase of TSH. |
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Authors:
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R V Mikelsaar; R Zordania; M Viikmaa; G Kudrjavtseva |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medical screening Volume: 5 ISSN: 0969-1413 ISO Abbreviation: J Med Screen Publication Date: 1998 |
Date Detail:
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Created Date: 1998-06-08 Completed Date: 1998-06-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9433359 Medline TA: J Med Screen Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 20-1 Citation Subset: IM |
Affiliation:
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Department of Human Biology and Genetics, University of Tartu, Estonia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Congenital Hypothyroidism* Estonia / epidemiology Female Humans Hypothyroidism / diagnosis*, epidemiology Infant, Newborn Male Neonatal Screening* Thyroid Hormones / analysis |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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