Document Detail

Neonatal screening for congenital hypothyroidism in East Azerbaijan, Iran: the first report.
MedLine Citation:
PMID:  23060475     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the prevalence of congenital hypothyroidism (CH) among neonates in East Azerbaijan, Iran.
METHODS: A cross-sectional study conducted from 2009 to 2010. Most heel blood samples were taken between three and seven days of birth. Thyroid stimulating hormone (TSH) was tested using the enzyme-linked immunosorbent assay method. Neonates with abnormal screening results (TSH>20 mIU/L, T4<6.5 mg/dL) were re-examined. Data were analysed using SPSS software.
RESULTS: A total of 62,459 infants were screened. Of 1562 re-called subjects (re-call rate 2.5%), 94 cases with CH were detected, yielding a CH prevalence of 1:666 (female:male ratio 1:1.4).
CONCLUSION: The prevalence of CH in East Azerbaijan province is higher in comparison with worldwide levels. These results emphasize the importance of the neonatal screening programme.
Ali Hossein Zeinalzadeh; Malihe Talebi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-11
Journal Detail:
Title:  Journal of medical screening     Volume:  19     ISSN:  1475-5793     ISO Abbreviation:  J Med Screen     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-24     Completed Date:  2013-03-28     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  9433359     Medline TA:  J Med Screen     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-6     Citation Subset:  IM    
Department of Community Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
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MeSH Terms
Congenital Hypothyroidism / diagnosis*,  epidemiology,  genetics*
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay / methods
Infant, Newborn
Maternal Age
Neonatal Screening / methods*
Reagent Kits, Diagnostic
Reproducibility of Results
Sensitivity and Specificity
Thyrotropin / analysis
Reg. No./Substance:
0/Reagent Kits, Diagnostic; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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