| Neonatal screening for congenital hypothyroidism in West Black Sea area, Turkey. | |
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MedLine Citation:
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PMID: 15857333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate the incidence of congenital hypothyroidism (CH) in the West Black Sea Area, a mild-to-moderate iodine deficient area in Turkey. Neonatal screening for CH was performed using blood specimens collected onto filter paper. Thyrotropin [thyroid-stimulating hormone (TSH)] was measured by radioimmunoassay, and a value >20 microU/ml was considered as cut-off point for re-examining. Venous serum was obtained to measure TSH, thyroxin (T4), free T4 (FT4) and thyroglobulin (TG). To determine the iodine status of the study area, median urinary iodine was measured in 212 randomly selected neonates and their mothers. A total of 18606 neonates were screened from three cities (Bolu, Düzce, and Zonguldak) between 2000 and 2002. With a cut-off point of TSH value >20 microU/ml, the recall rate was found 1.6%. Eight cases of CH were diagnosed (incidence 1/2326). There were three cases of transient hypothyroidism, with an incidence of 1/6202. Twenty-six percent of the TSH values was greater than 5 microU/ml. Median urinary iodine concentrations in neonates and their mothers were 85 microg/l and 40 microg/l, respectively. The incidences of CH, transient hypothyroidism and the recall rate were higher in our study area than many countries in Europe. The study area has been affected by mild-to-moderate iodine deficiency. Neonatal screening for CH should be introduced in Turkey without delay. A national comprehensive infantile hypothyroidism and iodine prophylaxis policies should be developed. |
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Authors:
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E Simsek; M Karabay; K Kocabay |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical practice Volume: 59 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-04-28 Completed Date: 2005-07-28 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 336-41 Citation Subset: IM |
Affiliation:
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Abant Izzet Baysal University, Düzce School of Medicine, Department of Pediatrics, Düzce, Turkey. enversimsek06@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Congenital Hypothyroidism* Female Humans Hypothyroidism / blood, epidemiology Incidence Infant Infant, Newborn Iodine / deficiency Male Neonatal Screening / methods Thyroglobulin / blood Thyrotropin / blood Thyroxine / blood Turkey / epidemiology |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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