Document Detail

Neonatal screening for congenital hypothyroidism in West Black Sea area, Turkey.
MedLine Citation:
PMID:  15857333     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the incidence of congenital hypothyroidism (CH) in the West Black Sea Area, a mild-to-moderate iodine deficient area in Turkey. Neonatal screening for CH was performed using blood specimens collected onto filter paper. Thyrotropin [thyroid-stimulating hormone (TSH)] was measured by radioimmunoassay, and a value >20 microU/ml was considered as cut-off point for re-examining. Venous serum was obtained to measure TSH, thyroxin (T4), free T4 (FT4) and thyroglobulin (TG). To determine the iodine status of the study area, median urinary iodine was measured in 212 randomly selected neonates and their mothers. A total of 18606 neonates were screened from three cities (Bolu, Düzce, and Zonguldak) between 2000 and 2002. With a cut-off point of TSH value >20 microU/ml, the recall rate was found 1.6%. Eight cases of CH were diagnosed (incidence 1/2326). There were three cases of transient hypothyroidism, with an incidence of 1/6202. Twenty-six percent of the TSH values was greater than 5 microU/ml. Median urinary iodine concentrations in neonates and their mothers were 85 microg/l and 40 microg/l, respectively. The incidences of CH, transient hypothyroidism and the recall rate were higher in our study area than many countries in Europe. The study area has been affected by mild-to-moderate iodine deficiency. Neonatal screening for CH should be introduced in Turkey without delay. A national comprehensive infantile hypothyroidism and iodine prophylaxis policies should be developed.
E Simsek; M Karabay; K Kocabay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical practice     Volume:  59     ISSN:  1368-5031     ISO Abbreviation:  Int. J. Clin. Pract.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-28     Completed Date:  2005-07-28     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  9712381     Medline TA:  Int J Clin Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  336-41     Citation Subset:  IM    
Abant Izzet Baysal University, Düzce School of Medicine, Department of Pediatrics, Düzce, Turkey.
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MeSH Terms
Child, Preschool
Congenital Hypothyroidism*
Hypothyroidism / blood,  epidemiology
Infant, Newborn
Iodine / deficiency
Neonatal Screening / methods
Thyroglobulin / blood
Thyrotropin / blood
Thyroxine / blood
Turkey / epidemiology
Reg. No./Substance:
7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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