Document Detail

Neonatal schizencephaly: comparison of brain imaging.
MedLine Citation:
PMID:  2127354     Owner:  NLM     Status:  MEDLINE    
Schizencephaly is a regional disturbance of cerebral hemisphere formation occurring at 3-5 months gestation; neonatal presentation is uncommon. Three neonates with schizencephaly were evaluated with cranial ultrasonography (US), unenhanced computed tomography (CT), and magnetic resonance imaging (MRI) examinations. Common findings in US, CT, and MRI include parasylvian and midline clefts, size asymmetries of the basal ganglia and thalamus, cerebral parenchymal volume loss, ventriculomegaly, ventricular diverticula, and absence of the septum pellucidum. MRI and CT were superior to US in detecting calcification, gyral and sulcal abnormalities, and parasylvian clefts. MRI alone demonstrated homolateral absence of the sylvian vasculature, small medullary pyramids, low position of the fornix, and the thinning of the corpus callosum. Although US appears adequate as a screening test, MRI best defines the precise pathoanatomic findings of neonatal schizencephaly and allows for the prediction of neurologic outcomes in affected newborns.
M C Chamberlain; G A Press; R F Bejar
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  6     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:    1990 Nov-Dec
Date Detail:
Created Date:  1991-04-15     Completed Date:  1991-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  382-7     Citation Subset:  IM    
Department of Neurosciences, University of California, San Diego 92103.
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MeSH Terms
Brain / abnormalities*,  pathology
Diagnostic Imaging*
Epilepsies, Partial / congenital*,  diagnosis
Follow-Up Studies
Hemiplegia / congenital*,  diagnosis
Infant, Newborn
Magnetic Resonance Imaging
Mental Retardation / diagnosis*
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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