Document Detail

Neonatal portal vein thrombosis: Diagnosis and management.
MedLine Citation:
PMID:  21925985     Owner:  NLM     Status:  Publisher    
Neonatal portal vein thrombosis (PVT) is an increasingly recognized event. Patients are generally asymptomatic in the neonatal period. The diagnosis is made with Doppler ultrasound. Umbilical catheterization, exchange transfusion and sepsis are risk factors for neonatal PVT. Thrombophilia is possibly a contributing risk factor. Although there are potential serious acute complications such as hepatic necrosis, the outcome is good in the majority of cases, followed up to 8 years of age. Thrombus resolution occurs in 30-70% in days to months. Liver lobe atrophy may occur following PVT, and does not appear to be associated with any impairment of liver function. Non-occlusive thrombosis is more likely to resolve than non-occlusive thrombosis. A subset of patients without resolution is at risk for developing portal hypertension over the next decade of life. There are no current defining features present during the neonatal period to enable identification of neonates at risk for portal hypertension. There is no evidence that anticoagulation therapy improves time to resolution or decreases the likelihood of portal hypertension. Anticoagulation therapy may be considered. A management algorithm is proposed.
Suzan Williams; Anthony K C Chan
Related Documents :
16935105 - Minimally invasive correction of pectus excavatum in adult patients.
2806735 - Training inspiratory resistance in duchenne dystrophy using adapted computer games.
15621465 - Rapid pleurodesis in symptomatic malignant pleural effusion.
18568555 - Improvement in respiratory function by percutaneous vertebroplasty.
17874125 - Nuttall technique: a method for subumbilical incisional hernia repair revised.
12883305 - Stimulation with fatty meal (lipomul) to assess gallbladder emptying in children with c...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-16
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  -     ISSN:  1878-0946     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Department of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neuroprotection with hypothermia in the newborn with hypoxic-ischaemic encephalopathy. standard guid...
Next Document:  Pre-expansion before risk reducing mastectomy combined with lipomodelling to enhance results from im...