Document Detail

Neonatal polycythemia and hyperviscosity.
MedLine Citation:
PMID:  18424246     Owner:  NLM     Status:  MEDLINE    
Neonatal polycythemia and hyperviscosity are defined as a hematocrit > or =65% and a viscosity value >2 standard deviations greater than the norm. Although polycythemia can reflect normal fetal adaptation, it has been thought to be responsible for abnormalities in the neonate. Polycythemia and hyperviscosity are associated with blood-flow changes in some organs, which alter their function. Partial exchange transfusion (PET) has been used to treat both symptomatic and asymptomatic patients. At present, no data support the use of PET in asymptomatic infants; the potential benefit in symptomatic infants depends on the symptoms. Studies of long-term neurodevelopmental status do not show any clear long-term benefits for PET. Crystalloids are as effective as colloids in PET and have the advantage of being cheaper and more readily available; also, they do not confer any risk of infection or anaphylaxis.
Shikha Sarkar; Ted S Rosenkrantz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  13     ISSN:  1744-165X     ISO Abbreviation:  -     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  248-55     Citation Subset:  IM    
Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
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MeSH Terms
Blood Viscosity / physiology*
Exchange Transfusion, Whole Blood / methods
Infant, Newborn
Isotonic Solutions
Polycythemia / diagnosis,  etiology,  physiopathology*,  therapy
Reg. No./Substance:
0/Colloids; 0/Isotonic Solutions

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