Document Detail

Neonatal pemphigus vulgaris.
MedLine Citation:
PMID:  18789074     Owner:  NLM     Status:  MEDLINE    
A male newborn with skin erosions was born to a 32-year-old woman who was under treatment for pemphigus vulgaris that had been diagnosed 16 months earlier. Antibodies to desmoglein (Dsg)1 and Dsg3 were analyzed by enzyme-linked immunosorbent assay. Index values of antibodies to Dsg1 and Dsg3 were 49 (normal index values, <14) and 121 (normal index values, <7), respectively. Those findings concluded a diagnosis of neonatal pemphigus vulgaris. No new vesicles or bullae appeared in the newborn after the birth. Non-corticosteroid ointments produced prompt epithelialization on the erosive lesions. All the eruptions disappeared in 3 weeks. The level of serum anti-Dsg3 autoantibodies when measured at the 76th day was negative (<5).
Makiko Gushi; Yu-Ichi Yamamoto; Yoshiko Mine; Ryoko Awazawa; Kimiko Nonaka; Kiyohito Taira; Yutaka Asato; Keisuke Hagiwara; Hiroshi Uezato
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of dermatology     Volume:  35     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  529-35     Citation Subset:  IM    
Division of Dermatology, Department of Organ-oriented Medicine, School of Medicine, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage
Autoantibodies / blood
Biological Markers / blood
Desmoglein 1 / immunology
Desmoglein 3 / immunology
Infant, Newborn
Pemphigus / diagnosis*,  drug therapy,  pathology
Pregnancy Complications
Skin / pathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Autoantibodies; 0/Biological Markers; 0/DSG1 protein, human; 0/DSG3 protein, human; 0/Desmoglein 1; 0/Desmoglein 3

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