Document Detail


Neonatal pattern of adrenergic metabolites in urine of small for gestational age and preterm infants.
MedLine Citation:
PMID:  6778954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Catecholamines (DA, NE, E), methoxyamines (MT, NMN, MN), DOPA and DOPAC were studied in urine of term small for gestational age infants (SGA) and preterm with appropriate birthweights for gestational age (PT) during the first ten days of life. Results were compared to values obtained for full term infants (FT). As a whole no deficit in urine catecholamines was observed in either group of SGA and PT neonates suggesting that capacities to synthesize catecholamines are already developed at birth. Furthermore, in SGA infants, adrenergic function seems to be enhanced during the first four days of life; however, SGA infants with low blood glucose levels excreted amounts of epinephrine similar to those of FT neonates, but much lower than those obtained in normoglycemic SGA neonates. These data suggest that enhanced release of catecholamines is required in SGA infants to maintain the glycemic homeostasis. In premature infants, the adrenergic pattern was highly altered only in younger preterm neonates (31 weeks of gestational age) who excreted more catecholamines than older preterm babies (33 to 36 weeks) or full term neonates; this catecholamine increase in urine of young preterm infants might be related to immaturity of storage vesicles and/or to thermoregulatory or respiratory events. On the other hand, a striking deficit in excretion of DOPAC was observed in small for gestational age infants and in young preterm neonates during the first ten days of life. DOPAC excretion was even lower in SGA than in young preterm neonates. These findings suggest that the maturation of dopaminergic neurons occurs late in gestational age and is greatly dependent on nutritional factors.
Authors:
Y Dalmaz; L Peyrin; J Dutruge; L Sann
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neural transmission     Volume:  49     ISSN:  0300-9564     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1980  
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  151-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / urine
Catecholamines / urine*
Creatinine / urine
Dihydroxyphenylalanine / urine
Dopamine / urine
Epinephrine / urine
Humans
Infant, Newborn
Infant, Premature*
Infant, Small for Gestational Age*
Metanephrine / urine
Norepinephrine / urine
Normetanephrine / urine
Chemical
Reg. No./Substance:
0/Catecholamines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 5001-33-2/Metanephrine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 60-27-5/Creatinine; 63-84-3/Dihydroxyphenylalanine; 97-31-4/Normetanephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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