Document Detail

Neonatal parathyroid secretion and renal receptor maturation in premature infants.
MedLine Citation:
PMID:  210849     Owner:  NLM     Status:  MEDLINE    
16 premature infants with normal trophicity were studied during the 1st week of life using serum parathormone (IPTH) dosage and evaluation of renal tubule maturation by the effect of exogenous parathormone (PTE) on urinary elimination of 3':5'-cyclic adenosine monophosphate (cAMP). As of the 1st day, IPTH levels reached or surpassed those in the adult. Prematurity thus does not appear to influence parathormone response. Given the specificity of the dosage antiserum, it appears reasonable that the PTH detected is biologically active. After PTE, urinary elimination of cAMP does not appreciably increase until the 6th day, while still remaining much lower than adult levels. The lower the weight of the premature infant, the less intense the response of the kidney. It thus seems possible that the later development of renal parathormone receptor in the premature infant may be a factor responsible for neonatal hypocalcemia with hyperphosphatemia.
E Mallet; J P Basuyau; P Brunelle; A M Devaux; C Fessard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  33     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1978  
Date Detail:
Created Date:  1978-11-29     Completed Date:  1978-11-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  304-8     Citation Subset:  IM    
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MeSH Terms
Body Weight
Cyclic AMP / urine
Gestational Age
Infant, Newborn
Infant, Premature*
Kidney / growth & development*,  physiology
Kidney Tubules / growth & development
Parathyroid Hormone / blood,  secretion*
Phosphates / urine
Receptors, Cell Surface / physiology*
Reg. No./Substance:
0/Parathyroid Hormone; 0/Phosphates; 0/Receptors, Cell Surface; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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