Document Detail


Neonatal outcomes in women with sonographically identified uterine leiomyomata.
MedLine Citation:
PMID:  22409539     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective. We sought to compare perinatal outcomes between women with and without leiomyomata. Study design. This is a retrospective cohort study comparing neonatal outcomes in women with and without uterine leiomyomata discovered at routine second trimester obstetric ultrasonography, all of whom delivered at a single institution. Potential confounders such as maternal age, parity, race, ethnicity, medical insurance, previous uterine surgery, fetal presentation, length of labor, mode of delivery, presence of placenta previa, placental abruption, chorioamnionitis, and epidural use were controlled for using multivariable logistic regression. Results. From 1993 to 2003, 15,104 women underwent routine second trimester prenatal ultrasonography, with 401 (2.7%) women identified with at least one leiomyoma. By univariate and multivariable analyses, the presence of leiomyomata was associated with statistically significant increased risks for preterm delivery at <34 weeks [adjusted odds ratio (AOR) 1.7, 95% confidence interval (CI) 1.1-2.6], <32 weeks (AOR 1.9, 95% CI 1.2-3.2), and <28 weeks (AOR 2.0, 95% CI 1.1-3.8). An association with increased risk for intrauterine fetal demise (IUFD) was also demonstrated (AOR 2.7, 95% CI 1.0-6.9). When IUFD was examined before and after 32 weeks' gestation, the finding only persisted at earlier gestational ages (<32 weeks: AOR 4.2, 95% CI 1.2-14.7 vs. >32 weeks: AOR 0.82, 95% CI 0.1-6.2). Conclusion. Regardless of maternal age, ethnicity, and parity, pregnant women with leiomyomata are at increased risk for preterm birth and IUFD. This did not translate to lower birth weight outcomes among term patients, suggesting that LBW is more likely due to preterm birth than growth restriction. These results may be useful for preconception and prenatal counseling of women with leiomyomata.
Authors:
Jasmine Lai; Aaron B Caughey; G Iram Qidwai; Alison F Jacoby
Related Documents :
17906019 - Obstetric outcomes in cancer survivors.
8993789 - A prospective study of reproductive factors, oral contraceptive use, and risk of colore...
25196649 - Elevated platelet-derived growth factor ab/bb is associated with a lower risk of recurr...
17721999 - Talcum powder, chronic pelvic inflammation and nsaids in relation to risk of epithelial...
15609319 - Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in the ne...
25264239 - Observe-5: observational postmarketing safety surveillance registry of etanercept for t...
18798229 - Perceived family history risk and symptomatic diagnosis of prostate cancer: the north c...
24167669 - Serum leptin, adiponectin and endometrial cancer risk in chinese women.
18704719 - Prevalence and correlates of multiple cancer risk behaviors in an australian population...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Reproductive Medicine, University of California, San Diego, CA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Stability of Superparamagnetic Iron Oxide Nanoparticles at Different pH Values: Experimental and The...
Next Document:  ?H2AX, pChk1 and Wip1 as potential markers of persistent DNA damage derived from DBP and PAH-contain...