Document Detail

Neonatal outcomes after demonstrated fetal lung maturity before 39 weeks of gestation.
MedLine Citation:
PMID:  21099593     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare outcomes among neonates delivered after documentation of fetal lung maturity before 39 weeks and those delivered at 39 or 40 weeks.
METHODS: This was a retrospective cohort study of women with singleton pregnancy delivered at 36 0/7 to 38 6/7 weeks after positive fetal lung maturity testing (based on amniotic fluid lecithin to sphingomyelin ratio) or at 39 0/7 to 40 6/7 weeks (without maturity testing) at our center from 1999 to 2008. Women with fetuses with major congenital anomalies, cord prolapse, nonreassuring antepartum testing, placental abruption, or oligohydramnios were excluded. A primary composite neonatal outcome included death, adverse respiratory outcomes, hypoglycemia, treated hyperbilirubinemia, generalized seizures, necrotizing enterocolitis, hypoxic ischemic encephalopathy, periventricular leukomalacia, and suspected or proven sepsis.
RESULTS: There were 459 neonates delivered at 36 to 38 weeks and 13,339 delivered at 39 to 40 weeks; mean birth weight was 3,107±548 g and 3,362±439 g, respectively. The risk of the composite adverse neonatal outcome was 6.1% for the 36- to 38-week group compared with 2.5% for the 39- to 40-week group (relative risk 2.4; confidence interval [CI] 1.7-3.5). After multivariable adjustment, early delivery remained significantly associated with an increased risk of the composite outcome (adjusted odds ratio [OR]1.7; CI 1.1-2.6) as well as several individual outcomes, including respiratory distress syndrome (adjusted OR 7.6; CI 2.2-26.6), treated hyperbilirubinemia (adjusted OR 11.2; CI 3.6-34), and hypoglycemia (adjusted OR 5.8; CI 2.4-14.3).
CONCLUSION: Neonates delivered at 36 to 38 weeks after confirmed fetal lung maturity are at higher risk of adverse outcomes than those delivered at 39 to 40 weeks.
Elizabeth Bates; Dwight J Rouse; Merry Lynn Mann; Victoria Chapman; Waldemar A Carlo; Alan T N Tita
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  116     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-04     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1288-95     Citation Subset:  AIM; IM    
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MeSH Terms
Cesarean Section
Fetal Organ Maturity*
Gestational Age*
Infant, Newborn
Infant, Newborn, Diseases / epidemiology
Lung / embryology*
Term Birth*
Grant Support
5 K12 HD01258-09/HD/NICHD NIH HHS; K12 HD001258/HD/NICHD NIH HHS
Comment In:
Obstet Gynecol. 2011 May;117(5):1228-9; author reply 1229   [PMID:  21508772 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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