Neonatal outcomes after demonstrated fetal lung maturity before 39 weeks of gestation.

Neonatal outcomes after demonstrated fetal lung maturity before 39 weeks of gestation.

MedLine Citation:	PMID: 21099593 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	OBJECTIVE: To compare outcomes among neonates delivered after documentation of fetal lung maturity before 39 weeks and those delivered at 39 or 40 weeks. METHODS: This was a retrospective cohort study of women with singleton pregnancy delivered at 36 0/7 to 38 6/7 weeks after positive fetal lung maturity testing (based on amniotic fluid lecithin to sphingomyelin ratio) or at 39 0/7 to 40 6/7 weeks (without maturity testing) at our center from 1999 to 2008. Women with fetuses with major congenital anomalies, cord prolapse, nonreassuring antepartum testing, placental abruption, or oligohydramnios were excluded. A primary composite neonatal outcome included death, adverse respiratory outcomes, hypoglycemia, treated hyperbilirubinemia, generalized seizures, necrotizing enterocolitis, hypoxic ischemic encephalopathy, periventricular leukomalacia, and suspected or proven sepsis. RESULTS: There were 459 neonates delivered at 36 to 38 weeks and 13,339 delivered at 39 to 40 weeks; mean birth weight was 3,107±548 g and 3,362±439 g, respectively. The risk of the composite adverse neonatal outcome was 6.1% for the 36- to 38-week group compared with 2.5% for the 39- to 40-week group (relative risk 2.4; confidence interval [CI] 1.7-3.5). After multivariable adjustment, early delivery remained significantly associated with an increased risk of the composite outcome (adjusted odds ratio [OR]1.7; CI 1.1-2.6) as well as several individual outcomes, including respiratory distress syndrome (adjusted OR 7.6; CI 2.2-26.6), treated hyperbilirubinemia (adjusted OR 11.2; CI 3.6-34), and hypoglycemia (adjusted OR 5.8; CI 2.4-14.3). CONCLUSION: Neonates delivered at 36 to 38 weeks after confirmed fetal lung maturity are at higher risk of adverse outcomes than those delivered at 39 to 40 weeks.

Authors:	Elizabeth Bates; Dwight J Rouse; Merry Lynn Mann; Victoria Chapman; Waldemar A Carlo; Alan T N Tita
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Publication Detail:	Type: Journal Article; Research Support, N.I.H., Extramural
Journal Detail:	Title: Obstetrics and gynecology Volume: 116 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2010 Dec
Date Detail:	Created Date: 2010-11-24 Completed Date: 2011-01-04 Revised Date: 2013-05-16
Medline Journal Info:	Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States
Other Details:	Languages: eng Pagination: 1288-95 Citation Subset: AIM; IM
Affiliation:	Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA.
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MeSH Terms
Descriptor/Qualifier:	Cesarean Section Female Fetal Organ Maturity* Gestational Age* Humans Infant, Newborn Infant, Newborn, Diseases / epidemiology Lung / embryology* Pregnancy Term Birth*
Grant Support
ID/Acronym/Agency:	5 K12 HD01258-09/HD/NICHD NIH HHS; K12 HD001258/HD/NICHD NIH HHS
Comments/Corrections
Comment In:	Obstet Gynecol. 2011 May;117(5):1228-9; author reply 1229 [PMID: 21508772 ]

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