Document Detail

Neonatal outcome after prolonged preterm rupture of the membranes.
MedLine Citation:
PMID:  2301516     Owner:  NLM     Status:  MEDLINE    
Pulmonary hypoplasia was diagnosed in 14 of 88 infants (16%) delivered in 1983 to 1986 after rupture of the membranes of greater than or equal to 7 days with onset before 29 weeks' gestation. Logistic regression analysis applied to examine the relative importance of perinatal risk factors in the prediction of pulmonary hypoplasia showed that gestational age at onset of rupture of the membranes had a significant effect (p = 0.002) on the odds that pulmonary hypoplasia developed in the neonate, whereas the duration of rupture of the membranes (p = 0.11) and the degree of oligohydramnios (p = 0.65) did not. Postnatally, the presence of pulmonary hypoplasia was associated with the severity of skeletal compression deformities (p less than 0.0001). The development of skeletal compression deformities was associated with severe oligohydramnios (p = 0.05) and duration of rupture of the membranes (p = 0.02) but not gestational age at rupture of the membranes (p = 0.77). Gestational age at onset of rupture of the membranes being the best single predictor of pulmonary hypoplasia suggests that the stage of lung development at rupture of the membranes may be important.
A Rotschild; E W Ling; M L Puterman; D Farquharson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  162     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  AIM; IM    
Department of Pediatrics, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Abnormalities, Multiple
Bone and Bones / abnormalities
Fetal Membranes, Premature Rupture / physiopathology*
Infant, Newborn
Lung / abnormalities
Pregnancy Outcome*
Regression Analysis
Risk Factors
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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