| Neonatal outcome of 58 infants exposed to maternal buprenorphine in utero. | |
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MedLine Citation:
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PMID: 18474065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study the neonatal outcome of infants exposed to buprenorphine in utero. METHODS: We prospectively followed 54 buprenorphine-using pregnant women and their 58 infants. Urinary buprenorphine and norbuprenorphine concentrations in the mothers were measured prior to delivery, and in the infants during the first 3 days of life. The Finnegan score was used to evaluate neonatal abstinence syndrome. Other medical problems as well as social outcomes were recorded. RESULTS: All infants had buprenorphine in their urine. A total of 38 infants required 20 +/- 10 days (range 7-48 days) of morphine treatment for neonatal abstinence syndrome. The length of hospital stay for all infants was 25 +/- 19 days (range 3-125 days). The infants' highest urinary norbuprenorphine concentrations across their first 3 days of life correlated with the length of hospital stay and duration of morphine treatment (both p < 0.05). The mean birth weight and mean head circumference (n = 58) were below average (mean -0.7 standard deviation [SD] and mean -0.5 SD, respectively). Eleven infants were discharged home, 19 infants were placed in foster care and 28 infants were discharged with their mothers to Mother and Child homes or to other institutions. CONCLUSION: Maternal buprenorphine use at the time of birth may cause neonatal abstinence syndrome, requiring long-term hospitalization. Multiple social problems require a multidisciplinary team approach. |
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Authors:
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Timo Hytinantti; Hanna Kahila; Martin Renlund; Anna-Liisa Järvenpää; Erja Halmesmäki; Satu Kivitie-Kallio |
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Publication Detail:
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Type: Journal Article Date: 2008-05-16 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 97 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1040-4 Citation Subset: IM |
Affiliation:
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Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland. timo.hytinantti@hus.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Buprenorphine
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adverse effects*,
urine Female Humans Infant, Newborn Male Narcotic Antagonists / adverse effects* Opioid-Related Disorders / rehabilitation* Pregnancy Pregnancy Complications Prenatal Exposure Delayed Effects / epidemiology*, etiology*, urine Psychomotor Disorders / chemically induced, epidemiology* Substance Abuse, Intravenous / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Narcotic Antagonists; 52485-79-7/Buprenorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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