Document Detail

Neonatal outcome of 58 infants exposed to maternal buprenorphine in utero.
MedLine Citation:
PMID:  18474065     Owner:  NLM     Status:  MEDLINE    
AIM: To study the neonatal outcome of infants exposed to buprenorphine in utero. METHODS: We prospectively followed 54 buprenorphine-using pregnant women and their 58 infants. Urinary buprenorphine and norbuprenorphine concentrations in the mothers were measured prior to delivery, and in the infants during the first 3 days of life. The Finnegan score was used to evaluate neonatal abstinence syndrome. Other medical problems as well as social outcomes were recorded. RESULTS: All infants had buprenorphine in their urine. A total of 38 infants required 20 +/- 10 days (range 7-48 days) of morphine treatment for neonatal abstinence syndrome. The length of hospital stay for all infants was 25 +/- 19 days (range 3-125 days). The infants' highest urinary norbuprenorphine concentrations across their first 3 days of life correlated with the length of hospital stay and duration of morphine treatment (both p < 0.05). The mean birth weight and mean head circumference (n = 58) were below average (mean -0.7 standard deviation [SD] and mean -0.5 SD, respectively). Eleven infants were discharged home, 19 infants were placed in foster care and 28 infants were discharged with their mothers to Mother and Child homes or to other institutions. CONCLUSION: Maternal buprenorphine use at the time of birth may cause neonatal abstinence syndrome, requiring long-term hospitalization. Multiple social problems require a multidisciplinary team approach.
Timo Hytinantti; Hanna Kahila; Martin Renlund; Anna-Liisa Järvenpää; Erja Halmesmäki; Satu Kivitie-Kallio
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Publication Detail:
Type:  Journal Article     Date:  2008-05-16
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1040-4     Citation Subset:  IM    
Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland.
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MeSH Terms
Buprenorphine / adverse effects*,  urine
Infant, Newborn
Narcotic Antagonists / adverse effects*
Opioid-Related Disorders / rehabilitation*
Pregnancy Complications
Prenatal Exposure Delayed Effects / epidemiology*,  etiology*,  urine
Psychomotor Disorders / chemically induced,  epidemiology*
Substance Abuse, Intravenous / epidemiology
Reg. No./Substance:
0/Narcotic Antagonists; 52485-79-7/Buprenorphine

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