Document Detail

Neonatal and obstetric outcome of pregnancies conceived by ICSI or IVF.
MedLine Citation:
PMID:  16274611     Owner:  NLM     Status:  MEDLINE    
Intracytoplasmic sperm injection (ICSI) is currently widely used despite concern regarding pregnancy complications and outcome, specifically congenital malformations. The aim of this study was to compare the obstetric and neonatal outcome of pregnancies conceived by IVF and ICSI. Long-term follow-up was achieved through questionnaires sent to women who conceived after IVF/ICSI treatment. Information was obtained regarding 219 pregnancies (322 children) conceived after ICSI and 145 pregnancies (201 children) conceived after IVF. There were no significant differences between the ICSI and regular IVF pregnancies in regard to the couple's characteristics and the obstetric complications. The mean +/- SD birth weight of the singletons conceived after ICSI was similar to that of singletons conceived after IVF: 3001 +/- 703 versus 3059 +/- 643 g respectively. In both groups there was a high incidence of multiple pregnancies, Caesarean sections, prematurity and low birth weights. The incidence of congenital malformations following IVF or ICSI pregnancies was similar, 6.3 and 7.7% respectively, but was increased compared with the general Israeli population. In summary, concern remains regarding the incidence of congenital malformations after IVF and the long-term outcome of ICSI pregnancies. However, the present results are reassuring with regard to the obstetric and neonatal outcome of pregnancies conceived by ICSI compared with those achieved by IVF.
Ariel Hourvitz; Shai Pri-Paz; Jeoshuah Dor; Daniel S Seidman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  11     ISSN:  1472-6483     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-11-08     Completed Date:  2006-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  England    
Other Details:
Languages:  eng     Pagination:  469-75     Citation Subset:  IM    
IVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
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MeSH Terms
Abnormalities, Multiple / diagnosis
Birth Weight
Fertilization in Vitro / methods*
Follow-Up Studies
Infant, Newborn
Middle Aged
Pregnancy Complications
Pregnancy Outcome
Pregnancy, Multiple
Retrospective Studies
Risk Factors
Sperm Injections, Intracytoplasmic / methods*
Treatment Outcome

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