Document Detail


Neonatal nucleated red blood cells in infants of overweight and obese mothers.
MedLine Citation:
PMID:  17634171     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The perinatal outcome of the infant of obese mother is adversely affected and in theory, may involve fetal hypoxia. We hypothesized that an index of fetal hypoxia, the neonatal nucleated red blood cell (NRBC) count, is elevated in infants of overweight and obese mothers. STUDY DESIGN: Absolute NRBC counts taken during the first 12 hours of life in 41 infants of overweight and obese mothers were compared to 28 controls. RESULTS: Maternal body mass index and infant birthweight were significantly higher in the overweight and obese group (P < 0.01). Hematocrit, corrected white blood cell and lymphocyte counts did not differ between groups. The absolute NRBC count was higher (P = 0.01), and the platelet count lower (P = 0.05) in infants of overweight and obese mothers than in controls. In stepwise regression analysis, the absolute NRBC count in infants of overweight and obese mothers remained significantly higher even after taking into account birthweight or gestational age and Apgar scores (P < 0.02). CONCLUSION: Infants of overweight and obese mothers have increased nucleated red blood cells at birth compared with controls. We speculate that even apparently healthy fetuses of overweight and obese mothers are exposed to a subtle hypoxemic environment.
Authors:
Galit Sheffer-Mimouni; Francis B Mimouni; Shaul Dollberg; Dror Mandel; Varda Deutsch; Yoav Littner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  26     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-10-09     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-63     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anoxia / epidemiology,  etiology*
Apgar Score
Birth Weight
Case-Control Studies
Erythroblasts / metabolism*,  ultrastructure
Erythrocyte Count
Female
Gestational Age
Hematocrit
Humans
Infant, Newborn / blood*
Leukocyte Count
Lymphocyte Count
Mothers
Obesity / physiopathology*
Platelet Count
Pregnancy
Pregnancy Complications / physiopathology*
Pregnancy Outcome
Prospective Studies
Regression Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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