Document Detail

Neonatal neutrophilia: possible role of a humoral granulopoietic factor.
MedLine Citation:
PMID:  6969879     Owner:  NLM     Status:  MEDLINE    
During the first days of life, newborn infants have leucocytosis with marked neutrophilia and a "shift to the left," the mechanism for which is as yet unknown. In an attempt to elucidate whether humoral granulopoietic factor(s) plays a role in this phenomenon, serial measurements of urinary and serum colony-stimulating activity levels were made in healthy newborn infants and normal older controls. Twenty-four-hr urine collections, serum samples, and complete blood counts were obtained from 30 full-term normal infants 24 hr and 4 days after delivery and in 13 of them on the 14th and 28th days of life as well. Specimens were assayed for their colony stimulating activity levels by their ability to stimulate bone marrow cells from C3HB mice to grow into colonies in soft agar. Elevated neutrophil, band form, and monocyte counts were found during the first day of life, which gradually decreased thereafter. Serum and urinary colony-stimulating activity levels were significantly increased (3- to 5-fold) over the controls on the first and fourth days of life, but declined to normal values by the 14th and 28th days.
Y Barak; Y Blachar; S Levin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  14     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1026-8     Citation Subset:  IM    
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MeSH Terms
Age Factors
Colony-Stimulating Factors / analysis*
Granulocytes / physiology
Infant, Newborn
Infant, Newborn, Diseases / blood,  etiology*
Leukocyte Count
Leukocytosis / etiology*
Reg. No./Substance:
0/Colony-Stimulating Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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