Document Detail

Neonatal neutrophil activation is a function of labor length in preterm infants.
MedLine Citation:
PMID:  9853932     Owner:  NLM     Status:  MEDLINE    
To understand better the development of the neonatal immune system, we evaluated the role of labor length, gestational age, and mode of delivery on the expression of the neonatal neutrophil cell surface antigens CD11b, CD11c, CD15, CD33, and CD66b in premature newborns. Peripheral blood samples from 68 apparently healthy preterm infants were obtained within 12 h of birth and incubated with MAb to the CD antigens. Samples were lysed, fixed, and analyzed by flow cytometry. Multivariate analysis was used to study the simultaneous effect of the labor length and gestational age on the neonatal neutrophil cell surface antigen expression. A positive correlation was demonstrated between neutrophil antigen expression and labor length (p < 0.001-0.026) but not with the mode of delivery (p = 0.191-0.638). There was no significant correlation between expression of neutrophil antigens and gestational age at delivery (p = 0.057-0.866), except for CD15 (p = 0.010). Our results indicate labor length is a significant factor in neonatal neutrophil activation at birth. These findings are independent of gestational age in preterm newborns. Mode of delivery does not seem to influence neonatal neutrophil activation. The neutrophils of premature infants can be activated antenatally and/or during labor.
N P Weinschenk; A Farina; D W Bianchi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  44     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-08     Completed Date:  1999-03-08     Revised Date:  2005-11-21    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  942-5     Citation Subset:  IM    
Department of Pediatrics, Floating Hospital for Children, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
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MeSH Terms
Antigens, CD / blood
Antigens, CD15 / blood
Antigens, Differentiation, Myelomonocytic / blood
Antigens, Neoplasm*
Cell Adhesion Molecules*
Fetal Blood / immunology*
Infant, Newborn
Infant, Premature / blood*,  immunology*
Integrin alphaXbeta2 / blood
Macrophage-1 Antigen / blood
Membrane Glycoproteins / blood
Neutrophil Activation / immunology*
Obstetric Labor, Premature / blood*,  immunology*
Time Factors
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD15; 0/Antigens, Differentiation, Myelomonocytic; 0/Antigens, Neoplasm; 0/CD33 antigen; 0/CEACAM8 protein, human; 0/Cell Adhesion Molecules; 0/Integrin alphaXbeta2; 0/Macrophage-1 Antigen; 0/Membrane Glycoproteins

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