Document Detail

Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.
MedLine Citation:
PMID:  1255326     Owner:  NLM     Status:  MEDLINE    
An uncoordinated and ineffectual sucking reflex is a major manifestation of neonatal narcotic abstinence and may have important consequences for the infant's subsequent well being. Measures of nutritive sucking were used to monitor the severity of neonatal narcotic abstinence in a series of infants born to narcotic-dependent mothers who were either attending the methadone clinic or else were "street addicts." In all these infants, sucking measures were significantly reduced relative to normal control subjects. Furthermore, the sucking behavior of infants born to mothers attending the methadone clinic was significantly more depressed than that of infants born to street addicts. In regard to the salutary effects of pharmacotherapy for neonatal narcotic abstinence, infants treated with paregoric approached normal control levels and showed significantly better sucking than those treated with phenobarbital or diazepam. The latter drug practically eliminated all spontaneous nutritive sucking behavior.
R E Kron; M Litt; D Eng; M D Phoenix; L P Finnegan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  88     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-06-02     Completed Date:  1976-06-02     Revised Date:  2010-04-27    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  637-41     Citation Subset:  AIM; IM    
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MeSH Terms
Diazepam / therapeutic use*
Infant, Newborn
Infant, Newborn, Diseases / drug therapy*,  etiology,  physiopathology
Methadone / therapeutic use*
Opium / therapeutic use*
Phenobarbital / therapeutic use*
Pregnancy Complications / rehabilitation
Substance Withdrawal Syndrome / drug therapy*,  physiopathology
Sucking Behavior / drug effects*
Reg. No./Substance:
439-14-5/Diazepam; 50-06-6/Phenobarbital; 76-99-3/Methadone; 8008-60-4/Opium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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