Document Detail


Neonatal myasthenia gravis: specific advantages of repetitive stimulation over edrophonium testing.
MedLine Citation:
PMID:  3242526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A premature infant with neonatal myasthenia gravis is presented to illustrate the utility of electrodiagnosis. The patient, born to a mother with myasthenia gravis, suffered additional problems, including hypoxia and subependymal hemorrhage which potentially contributed to hypotonia and poor respiratory effort, thus complicating the diagnosis. Standard testing with edrophonium originally was negative which cast doubt on the diagnosis; however, a repetitive motor nerve stimulation test demonstrated a significant decremental response which was consistent with neonatal myasthenia gravis. This decremental response was corrected following intravenous infusion of edrophonium. In the newborn with suspected myasthenia gravis, repetitive motor nerve stimulation may be a more reliable diagnostic procedure than the more frequently recommended pharmacologic tests. Use of this electrodiagnostic procedure in combination with pharmacologic testing may improve diagnostic accuracy in the premature infant and lead to earlier treatment.
Authors:
R M Hays; L J Michaud
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  4     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:    1988 Jul-Aug
Date Detail:
Created Date:  1989-06-06     Completed Date:  1989-06-06     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Affiliation:
Department of Rehabilitation Medicine, Children's Hospital and Medical Center, Seattle 98105.
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MeSH Terms
Descriptor/Qualifier:
Edrophonium / therapeutic use*
Humans
Infant
Infant, Newborn
Infant, Premature, Diseases / diagnosis*,  drug therapy,  physiopathology
Male
Motor Neurons / physiology
Myasthenia Gravis / diagnosis*,  drug therapy,  physiopathology
Pyridostigmine Bromide / therapeutic use*
Chemical
Reg. No./Substance:
101-26-8/Pyridostigmine Bromide; 312-48-1/Edrophonium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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