Document Detail

Neonatal morbidity and mortality secondary to premature rupture of membranes.
MedLine Citation:
PMID:  1630737     Owner:  NLM     Status:  MEDLINE    
PROM is one of the most common complications of pregnancy that has a major impact on neonatal mortality and morbidity. The occurrence of PROM is either directly or indirectly responsible for a large number of premature births and the concomitant mortality and morbidity associated with preterm delivery. PROM turns a pregnancy into a high-risk situation and increases the need for neonatal resuscitation in the delivery room. The incidence of neonatal sepsis increases with PROM, but the overall outcome of the neonate, even with surfactant therapy, is still primarily dependent on the gestational age at the time of delivery. This is most relevant between 24 and 27 weeks' gestation. During this 3-week interval, survival improves by almost 2% for each additional day of in utero maturation (i.e., from 35 to 75%). Thus the benefit to the fetus of prolonging the pregnancy in cases of PROM is immensely worthwhile and should be aggressively pursued as long as there is no significant increase in maternal morbidity.
J M Klein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology clinics of North America     Volume:  19     ISSN:  0889-8545     ISO Abbreviation:  Obstet. Gynecol. Clin. North Am.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-08-20     Completed Date:  1992-08-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8709551     Medline TA:  Obstet Gynecol Clin North Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265-80     Citation Subset:  IM    
Department of Pediatrics, University of Iowa, Iowa City.
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MeSH Terms
Fetal Membranes, Premature Rupture / complications*
Infant, Newborn
Infant, Newborn, Diseases / embryology*,  mortality*

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