Document Detail


Neonatal lupus syndrome in a Nigerian child.
MedLine Citation:
PMID:  22605870     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal lupus is a rare syndrome resulting from passively transferred maternal autoantibodies during pregnancy. A male infant was delivered at term to a 29-year-old primiparous woman who was diagnosed of systemic lupus erythematosus 2 years earlier and had detectable levels of autoantibodies (antinuclear antibody (ANA), anti-dsDNA, anti-Ro and anti-La/SSB) in second trimester. However, the pregnancy was otherwise uneventful. He presented at the age of 8 week with a widespread hypopigmented macular rash on the trunk and patchy alopecia involving the hair line and the occipito-parietal regions of 3 weeks duration, anaemia and symptomatic thrombocytopaenia. Serologic test for autoantibodies was positive for ANA and anti-La/SSB. Further evaluation was normal. He was managed conservatively with blood products and topical corticosteroids. Mother was also advised to avoid direct exposure to sunlight and fluorescent light. Haematological parameters gradually normalised over 2 months and the skin lesions resolved completely by the age of 6 months.
Authors:
Moses Abiodun; Olufemi Adelowo
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-05-11
Journal Detail:
Title:  BMJ case reports     Volume:  2012     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-12     Revised Date:  2014-05-16    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adrenal Cortex Hormones / administration & dosage
Blood Component Transfusion
Diagnosis, Differential
Humans
Infant, Newborn
Lupus Erythematosus, Systemic / congenital*,  diagnosis,  drug therapy
Male
Nigeria
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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